RNA N1-methyladenosine regulator-mediated methylation modification patterns and heterogeneous signatures in glioma

被引:12
作者
Mao, Meng [1 ,2 ,3 ]
Chu, Qinjun [1 ]
Lou, Yongli [4 ]
Lv, Peipei [5 ]
Wang, Lin-jian [2 ,3 ,4 ]
机构
[1] Zhengzhou Univ, Dept Anesthesiol & Perioperat Med, Zhengzhou Cent Hosp, Zhengzhou, Peoples R China
[2] Zhengzhou Univ, Res Trauma Ctr, Zhengzhou Cent Hosp, Zhengzhou, Peoples R China
[3] Zhengzhou Univ, Coll Med, Ctr Adv Med, Zhengzhou, Peoples R China
[4] Zhengzhou Univ, Dept Neurosurg, Zhengzhou Cent Hosp, Zhengzhou, Peoples R China
[5] Zhengzhou Univ, Dept Radiol, Zhengzhou Cent Hosp, Zhengzhou, Peoples R China
来源
FRONTIERS IN IMMUNOLOGY | 2022年 / 13卷
基金
中国国家自然科学基金;
关键词
glioma; m(1)A; heterogeneity; stemness; tumor microenvironment; TMZ-resistance; ADJUVANT TEMOZOLOMIDE; LANDSCAPE; GLIOBLASTOMA; RADIOTHERAPY; CONCOMITANT; EXPRESSION; TRANSPORT; DATABASE;
D O I
10.3389/fimmu.2022.948630
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
N1-methyladenosine (m(1)A) is ubiquitous in eukaryotic RNA and regulates mRNA translation. However, little is known about its regulatory role in glioma. Here, we identified 4 m(1)A modification-related patterns based on m(1)A regulators in the TCGA (The Cancer Genome Atlas) and CGGA (Chinese Glioma Genome Atlas) cohorts. The differences in survival prognosis between different clusters were striking. In addition, stemness, genomic heterogeneity, tumor microenvironment (TME), and immune cell infiltration were also significantly different between the poor and best prognostic clusters. To reveal the underlying mechanism, differentially expressed genes (DEGs) between the poor and best prognostic clusters were identified, and then were integrated for weighted correlation network analysis (WGCNA). After Univariate Cox-LASSO-Multivariate Cox analyses, DEGs PLEK2 and ABCC3 were screened as the risk-hub genes and were selected to construct an m(1)A-related signature. Moreover, ABCC3 exacerbated glioma proliferation and was associated with temozolomide (TMZ) resistance. Overall, our study provided new insights into the function and potential therapeutic role of m(1)A in glioma.
引用
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页数:15
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共 42 条
  • [1] The landscape of somatic copy-number alteration across human cancers
    Beroukhim, Rameen
    Mermel, Craig H.
    Porter, Dale
    Wei, Guo
    Raychaudhuri, Soumya
    Donovan, Jerry
    Barretina, Jordi
    Boehm, Jesse S.
    Dobson, Jennifer
    Urashima, Mitsuyoshi
    Mc Henry, Kevin T.
    Pinchback, Reid M.
    Ligon, Azra H.
    Cho, Yoon-Jae
    Haery, Leila
    Greulich, Heidi
    Reich, Michael
    Winckler, Wendy
    Lawrence, Michael S.
    Weir, Barbara A.
    Tanaka, Kumiko E.
    Chiang, Derek Y.
    Bass, Adam J.
    Loo, Alice
    Hoffman, Carter
    Prensner, John
    Liefeld, Ted
    Gao, Qing
    Yecies, Derek
    Signoretti, Sabina
    Maher, Elizabeth
    Kaye, Frederic J.
    Sasaki, Hidefumi
    Tepper, Joel E.
    Fletcher, Jonathan A.
    Tabernero, Josep
    Baselga, Jose
    Tsao, Ming-Sound
    Demichelis, Francesca
    Rubin, Mark A.
    Janne, Pasi A.
    Daly, Mark J.
    Nucera, Carmelo
    Levine, Ross L.
    Ebert, Benjamin L.
    Gabriel, Stacey
    Rustgi, Anil K.
    Antonescu, Cristina R.
    Ladanyi, Marc
    Letai, Anthony
    [J]. NATURE, 2010, 463 (7283) : 899 - 905
  • [2] MODOMICS: a database of RNA modification pathways. 2017 update
    Boccaletto, Pietro
    Machnicka, Magdalena A.
    Purta, Elzbieta
    Piatkowski, Pawe
    Baginski, Blazej
    Wirecki, Tomasz K.
    de Crecy-Lagard, Valerie
    Ross, Robert
    Limbach, Patrick A.
    Kotter, Annika
    Helm, Mark
    Bujnicki, Janusz M.
    [J]. NUCLEIC ACIDS RESEARCH, 2018, 46 (D1) : D303 - D307
  • [3] Landscape of Microsatellite Instability Across 39 Cancer Types
    Bonneville, Russell
    Krook, Melanie A.
    Kautto, Esko A.
    Miya, Jharna
    Wing, Michele R.
    Chen, Hui-Zi
    Reeser, Julie W.
    Yu, Lianbo
    Roychowdhury, Sameek
    [J]. JCO PRECISION ONCOLOGY, 2017, 1 : 1 - 15
  • [4] The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data
    Cerami, Ethan
    Gao, Jianjiong
    Dogrusoz, Ugur
    Gross, Benjamin E.
    Sumer, Selcuk Onur
    Aksoy, Buelent Arman
    Jacobsen, Anders
    Byrne, Caitlin J.
    Heuer, Michael L.
    Larsson, Erik
    Antipin, Yevgeniy
    Reva, Boris
    Goldberg, Arthur P.
    Sander, Chris
    Schultz, Nikolaus
    [J]. CANCER DISCOVERY, 2012, 2 (05) : 401 - 404
  • [5] Trmt61B is a methyltransferase responsible for 1-methyladenosine at position 58 of human mitochondrial tRNAs
    Chujo, Takeshi
    Suzuki, Tsutomu
    [J]. RNA, 2012, 18 (12) : 2269 - 2276
  • [6] Identification of YTH Domain-Containing Proteins as the Readers for N1-Methyladenosine in RNA
    Dai, Xiaoxia
    Wang, Tianlu
    Gonzalez, Gwendolyn
    Wang, Yinsheng
    [J]. ANALYTICAL CHEMISTRY, 2018, 90 (11) : 6380 - 6384
  • [7] Recurrent glioma clinical trial, CheckMate-143: the game is not over yet
    Filley, Anna C.
    Henriquez, Mario
    Dey, Mahua
    [J]. ONCOTARGET, 2017, 8 (53) : 91779 - 91794
  • [8] RNA modifications modulate gene expression during development
    Frye, Michaela
    Harada, Bryan T.
    Behm, Mikaela
    He, Chuan
    [J]. SCIENCE, 2018, 361 (6409) : 1346 - 1349
  • [9] Detecting RNA modifications in the epitranscriptome: predict and validate
    Helm, Mark
    Motorin, Yuri
    [J]. NATURE REVIEWS GENETICS, 2017, 18 (05) : 275 - 291
  • [10] MRP3, an organic anion transporter able to transport anti-cancer drugs
    Kool, M
    van der Linden, M
    de Haas, M
    Scheffer, GL
    de Vree, JML
    Smith, AJ
    Jansen, G
    Peters, GJ
    Ponne, N
    Scheper, RJ
    Elferink, RPJO
    Baas, F
    Borst, P
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (12) : 6914 - 6919