Alkaloids Isolated from the Lateral Root of Aconitum carmichaelii

被引：64

作者：

Xiong, Liang ^{[1
,2
,3
]}

Peng, Cheng ^{[1
,2
,3
]}

Xie, Xiao-Fang ^{[1
,2
,3
]}

Guo, Li ^{[1
,2
,3
]}

He, Cheng-Jun ^{[1
,2
,3
]}

Geng, Zhao ^{[1
,2
,3
]}

Wan, Feng ^{[1
,2
,3
]}

Dai, Ou ^{[1
,2
,3
]}

Zhou, Qin-Mei ^{[1
,2
,3
]}

机构：

[1] Minist Sci & Technol, Chengdu 610075, Sichuan, Peoples R China

[2] Minist Educ, Key Lab Standardizat Chinese Herbal Med, Chengdu 610075, Sichuan, Peoples R China

[3] Chengdu Univ Tradit Chinese Med, Coll Pharm, Chengdu 610075, Sichuan, Peoples R China

来源：

MOLECULES | 2012年 / 17卷 / 08期

关键词：

Aconitum carmichaelii; lateral root; alkaloids; bioactivities; NORDITERPENOID ALKALOIDS; DERIVATIVES; ACID;

D O I：

10.3390/molecules17089939

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two new alkaloids, aconicarmine (1) and aconicaramide (5), were isolated from the EtOH extract of the lateral roots of Aconitum carmichaelii, together with five known compounds: fuziline (2), neoline (3), N-ethylhokbusine B (4), 5-hydroxymethylpyrrole-2-carbaldehyde (6), and oleracein E (7). Their structures were elucidated by physical and NMR analysis. Pyrrole alkaloids were isolated from A. carmichaelii for the first time. In the in vitro assays, compounds 2 and 3 showed activity against pentobarbital sodium-induced cardiomyocytes damage by obviously recovering beating rhythm and increasing the cell viability, while compounds 5 and 7 showed moderate antibacterial activity.

引用

页码：9939 / 9946

页数：8

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