Influence of 5-HT2 Receptor Agonist on Cardiac Pumping Function of Trained Offspring of Trained Rats

被引：1
作者：
Valeev, A. M. [1 ]
Abzalov, N. I. [1 ]
Abzalov, R. A. [1 ]
Nigmatullina, R. R. [1 ,2 ]
Abzalov, R. R. [1 ]
Nikitin, A. S. [1 ]
机构：
[1] Tatar State Humanitarian Pedag Univ, Kazan, Russia
[2] Kazan State Med Univ, Kazan, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2012年 / 153卷 / 03期
关键词：
muscle exercise; cardiac pumping function; heart rate; stroke volume; 5-HT2 receptor agonist; SEROTONIN;
D O I：
10.1007/s10517-012-1704-x
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
We studied cardiac pumping function in the offspring of rats subjected to swimming exercise and the offspring of untrained rats. The rat pups were adapted for swimming with stepwise increasing load from day 21 to 70 life. At the age of 21 and 70 days, offspring of trained rats showed lower HR and significantly higher stroke volume and cardiac output than offspring of untrained rats. Agonist of 5-HT2-receptors alpha-methyl-5-hydroxytryptamine maleate (30 mu g/kg) reduced enhanced stroke volume in trained offspring born by trained mothers. In trained offspring of untrained rats, the agonist had more pronounced effect on HR.
引用
收藏
页码：315 / 318
页数：4
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