Influence of 5-HT2 Receptor Agonist on Cardiac Pumping Function of Trained Offspring of Trained Rats

被引：1
作者：
Valeev, A. M. [1 ]
Abzalov, N. I. [1 ]
Abzalov, R. A. [1 ]
Nigmatullina, R. R. [1 ,2 ]
Abzalov, R. R. [1 ]
Nikitin, A. S. [1 ]
机构：
[1] Tatar State Humanitarian Pedag Univ, Kazan, Russia
[2] Kazan State Med Univ, Kazan, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2012年 / 153卷 / 03期
关键词：
muscle exercise; cardiac pumping function; heart rate; stroke volume; 5-HT2 receptor agonist; SEROTONIN;
D O I：
10.1007/s10517-012-1704-x
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
We studied cardiac pumping function in the offspring of rats subjected to swimming exercise and the offspring of untrained rats. The rat pups were adapted for swimming with stepwise increasing load from day 21 to 70 life. At the age of 21 and 70 days, offspring of trained rats showed lower HR and significantly higher stroke volume and cardiac output than offspring of untrained rats. Agonist of 5-HT2-receptors alpha-methyl-5-hydroxytryptamine maleate (30 mu g/kg) reduced enhanced stroke volume in trained offspring born by trained mothers. In trained offspring of untrained rats, the agonist had more pronounced effect on HR.
引用
收藏
页码：315 / 318
页数：4
相关论文
共 50 条
  • [21] The effects of 5-hydroxytryptamine 5-HT2 receptor antagonists on nerve conduction velocity and endoneurial perfusion in diabetic rats
    Cameron, NE
    Cotter, MA
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2003, 367 (06) : 607 - 614
  • [22] The effects of 5-hydroxytryptamine 5-HT2 receptor antagonists on nerve conduction velocity and endoneurial perfusion in diabetic rats
    Norman E. Cameron
    Mary A. Cotter
    Naunyn-Schmiedeberg's Archives of Pharmacology, 2003, 367 : 607 - 614
  • [23] 5-HT2 Receptor Regulation of Extracellular GABA Levels in the Prefrontal Cortex
    Walid M Abi-Saab
    Michael Bubser
    Robert H Roth
    Ariel Y Deutch
    Neuropsychopharmacology, 1999, 20 : 92 - 96
  • [24] Influence of serotonin and selective 5-HT2 and 5-HT3 receptor agonists on the haemodynamics of the isolated, constant pressure perfused rat heart
    G. Ciurzynska
    T. W. Deptuch
    M. Kurenko-Deptuch
    E. Wojtecka-Lukasik
    A. Witanowska
    D. Maslinska
    K. Tusinska
    M. Chciuk-Gornicka
    M. Gujski
    S. Maslinski
    Inflammation Research, 2005, 54 : S72 - S73
  • [25] Behavioral responses to stress following central and peripheral injection of the 5-HT2 agonist DOI
    Hawkins, MF
    Uzelac, SM
    Baumeister, AA
    Hearn, JK
    Broussard, JI
    Guillot, TS
    PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2002, 73 (03) : 537 - 544
  • [26] Blockade of striatal 5-HT2 receptors produces retrograde amnesia in rats
    Prado-Alcalá, RA
    Solana-Figueroa, R
    Galindo, LE
    Medina, AC
    Quirarte, GL
    LIFE SCIENCES, 2003, 74 (04) : 481 - 488
  • [27] THE HUMAN 5-HT2 RECEPTOR IS ENCODED BY A MULTIPLE INTRON EXON GENE
    CHEN, K
    YANG, W
    GRIMSBY, J
    SHIH, JC
    MOLECULAR BRAIN RESEARCH, 1992, 14 (1-2): : 20 - 26
  • [28] Sustained treatment with a 5-HT2A receptor agonist causes functional desensitization and reductions in agonist-labeled 5-HT2A receptors despite increases in receptor protein levels in rats
    Shi, Ju
    Landry, Michelle
    Carrasco, Gonzalo A.
    Battaglia, George
    Muma, Nancy A.
    NEUROPHARMACOLOGY, 2008, 55 (05) : 687 - 692
  • [29] 5-HT2 receptor regulation of extracellular GABA levels in the prefrontal cortex
    Abi-Saab, WM
    Bubser, M
    Roth, RH
    Deutch, AY
    NEUROPSYCHOPHARMACOLOGY, 1999, 20 (01) : 92 - 96
  • [30] Involvement of 5-HT2 receptor in imipramine-induced hyperglycemia in mice
    Sugimoto, Y
    Inoue, K
    Yamada, J
    HORMONE AND METABOLIC RESEARCH, 2003, 35 (09) : 511 - 516
12345