Influence of 5-HT2 Receptor Agonist on Cardiac Pumping Function of Trained Offspring of Trained Rats

被引：1
|
作者：
Valeev, A. M. [1 ]
Abzalov, N. I. [1 ]
Abzalov, R. A. [1 ]
Nigmatullina, R. R. [1 ,2 ]
Abzalov, R. R. [1 ]
Nikitin, A. S. [1 ]
机构：
[1] Tatar State Humanitarian Pedag Univ, Kazan, Russia
[2] Kazan State Med Univ, Kazan, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2012年 / 153卷 / 03期
关键词：
muscle exercise; cardiac pumping function; heart rate; stroke volume; 5-HT2 receptor agonist; SEROTONIN;
D O I：
10.1007/s10517-012-1704-x
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
We studied cardiac pumping function in the offspring of rats subjected to swimming exercise and the offspring of untrained rats. The rat pups were adapted for swimming with stepwise increasing load from day 21 to 70 life. At the age of 21 and 70 days, offspring of trained rats showed lower HR and significantly higher stroke volume and cardiac output than offspring of untrained rats. Agonist of 5-HT2-receptors alpha-methyl-5-hydroxytryptamine maleate (30 mu g/kg) reduced enhanced stroke volume in trained offspring born by trained mothers. In trained offspring of untrained rats, the agonist had more pronounced effect on HR.
引用
收藏
页码：315 / 318
页数：4
相关论文
共 50 条
  • [1] Influence of 5-HT2 Receptor Agonist on Cardiac Pumping Function of Trained Offspring of Trained Rats
    A. M. Valeev
    N. I. Abzalov
    R. A. Abzalov
    R. R. Nigmatullina
    R. R. Abzalov
    A. S. Nikitin
    Bulletin of Experimental Biology and Medicine, 2012, 153 : 315 - 318
  • [2] Role of 5-HT2B Serotonin Receptor Agonist in the Regulation of Pumping Function of the Heart
    R. A. Abzalov
    A. M. Valeev
    N. I. Abzalov
    A. A. Gulyakov
    Bulletin of Experimental Biology and Medicine, 2015, 159 : 302 - 304
  • [3] Role of 5-HT2B Serotonin Receptor Agonist in the Regulation of Pumping Function of the Heart
    Abzalov, R. A.
    Abzalov, R. R.
    Valeev, A. M.
    Abzalov, N. I.
    Gulyakov, A. A.
    BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2015, 159 (03) : 302 - 304
  • [4] Effects of a 5-HT2 receptor agonist and an antagonist on the behavior of rats with different choices of reinforcement value
    Zaichenko M.I.
    Merzhanova G.Kh.
    Vanetsian G.L.
    Neuroscience and Behavioral Physiology, 2014, 44 (5) : 506 - 512
  • [5] Restraint accentuates the effects of 5-HT2 receptor antagonists and a 5-HT1A receptor agonist on lordosis behavior
    Uphouse, L
    White, S
    Harrison, L
    Hiegel, C
    Majumdar, D
    Guptarak, J
    Truitt, WA
    PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2003, 76 (01) : 63 - 73
  • [6] ALCOHOL DRINKING IN RATS IS ATTENUATED BY THE MIXED 5-HT1 AGONIST 5-HT2 ANTAGONIST FG 5893
    SINGH, GK
    KALMUS, GW
    BJORK, AK
    MYERS, RD
    ALCOHOL, 1993, 10 (03) : 243 - 248
  • [7] Effects of corticosterone on 5-HT1A and 5-HT2 receptor binding and on the receptor-mediated behavioral responses of rats
    Takao, K
    Nagatani, T
    Kitamura, Y
    Yamawaki, S
    EUROPEAN JOURNAL OF PHARMACOLOGY, 1997, 333 (2-3) : 123 - 128
  • [8] Attenuated 5-HT2 receptor-mediated responses in hindquarters of diabetic rats
    James, GM
    Hodgson, WC
    EUROPEAN JOURNAL OF PHARMACOLOGY, 1995, 294 (01) : 109 - 115
  • [9] Effects of 5-HT1 and 5-HT2 Receptor Agonists on Electromagnetic Field-Induced Analgesia in Rats
    Ozdemir, Ercan
    Demirkazik, Ayse
    Taskiran, Ahmet Sevki
    Arslan, Gokhan
    BIOELECTROMAGNETICS, 2019, 40 (05) : 319 - 330
  • [10] Ketanserin, a 5-HT2 receptor antagonist, decreases nicotine self-administration in rats
    Levin, Edward D.
    Slade, Susan
    Johnson, Michael
    Petro, Ann
    Horton, Kofi
    Williams, Paul
    Rezvani, Amir H.
    Rose, Jed E.
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2008, 600 (1-3) : 93 - 97
12345