Monoacylglycerols as transmembrane Cl- anion transporters

被引：29

作者：

Bahmanjah, Soheila ^{[1
]}

Zhang, Ning ^{[1
]}

Davis, Jeffery T. ^{[1
]}

机构：

[1] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA

来源：

CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 37期

关键词：

CHLORIDE TRANSPORT; AMPHIPHILES; MONOLAYERS; DELIVERY;

D O I：

10.1039/c2cc18148g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report that the amphiphilic natural product, monoacylglycerol 1, functions as a transmembrane Cl-/NO3- anion transporter. The 1,2-diol group is crucial for the transport function since diacylglycerol and triacylglycerol analogs are not anion transporters. Furthermore, adding another hydrogen bond donor to the glycerol head-group and perfluorination of the acyl tail gave synthetic analogs with improved Cl- membrane transport properties.

引用

页码：4432 / 4434

页数：3

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