Are Mycobacterium avium subsp paratuberculosis and Epstein-Barr virus triggers of multiple sclerosis in Sardinia?

被引：29
|
作者：
Cossu, Davide [1 ]
Masala, Speranza [1 ]
Cocco, Eleonora [2 ]
Paccagnini, Daniela [1 ]
Frau, Jessica [2 ]
Marrosu, Maria Giovanna [2 ]
Sechi, Leonardo A. [1 ]
机构：
[1] Univ Sassari, Dipartimento Sci Biomed, Sez Microbiol Sperimentale & Clin, I-07100 Sassari, Italy
[2] Univ Cagliari, Ctr Sclerosi Multipla, Dipartimento Sci Cardiovasc & Neurol, I-09124 Cagliari, Italy
来源：
MULTIPLE SCLEROSIS JOURNAL | 2012年 / 18卷 / 08期
关键词：
Mycobacterium avium subsp; paratuberculosis; Epstein Barr virus; multiple sclerosis; Sardinian;
D O I：
10.1177/1352458511433430
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Sardinia acts as an ideal setting for multiple sclerosis (MS) studies because its prevalence of MS is one of the highest worldwide. Several pathogens have been investigated amongst 119 Sardinian MS patients and 117 healthy controls to determine whether they might have a role in triggering MS in genetically predisposed individuals. Mycobacterium avium subsp. paratuberculosis (MAP) and Epstein Barr virus DNA were detected in 27.5% and 17.3%, respectively, of the MS patients. Moreover an extremely high humoral immune response against MAP recombinant protein MAP FprB (homologous to human myelin P0) was observed, whereas no significant results were found against Mycobacterium tuberculosis FprA and Helicobacter pylori HP986 protein.
引用
收藏
页码：1181 / 1184
页数：4
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