Carriage of Neisseria meningitidis in Europe: a review of studies undertaken in the region

被引:0
作者
Soriano-Gabarro, Montse [1 ,2 ]
Wolter, Joanne [1 ]
Hogea, Cosmina [1 ]
Vyse, Andrew [1 ]
机构
[1] GlaxoSmithKline Biol, B-1300 Wavre, Belgium
[2] Bayer Schering Pharma, D-13352 Berlin, Germany
关键词
carriage; conjugate vaccine; epidemiology; Europe; Neisseria meningitidis; C CONJUGATE VACCINATION; MENINGOCOCCAL DISEASE; NASOPHARYNGEAL CARRIAGE; UNIVERSITY-STUDENTS; PHARYNGEAL CARRIAGE; ARMY RECRUITS; HERD-IMMUNITY; RISK-FACTORS; ASYMPTOMATIC CARRIAGE; SCHOOL POPULATION;
D O I
10.1586/ERI.11.89
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Meningococcal conjugate vaccines induce herd protection by preventing nasopharyngeal meningococcal acquisition, which is a prerequisite for invasive disease. Thus, meningococcal carriage epidemiology is important in understanding relationships between carriage and disease. A literature search traced information on meningococcal carriage in 27 EU countries. Meningococcal carriage prevalence differed within and between countries, varying across age groups, serogroup distribution and over time. Carriage prevalence increased during childhood, peaking in 15-24-year-olds. While serogroup B was usually the dominant serogroupable carried serogroup, serogroups C, W-135 and Y were also frequently carried. Current carriage studies in Europe are limited. New studies using standardized methods are needed to improve our understanding of meningococcal disease etiology and transmission, and to monitor the impact of meningococcal conjugate vaccines in populations.
引用
收藏
页码:761 / 774
页数:14
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