Nephroprotective Effects of Alhagi camelorum against Cisplatin-Induced Nephrotoxicity in Albino Wistar Rats

被引：13

作者：

Iqbal, Muhammad Omer ^{[1
,2
]}

Ahmed, Muhammad Masood ^{[3
,4
]}

Arshad, Shafia ^{[5
]}

Javaid, Usman ^{[6
]}

Khan, Imran Ahmad ^{[2
,7
]}

Manzoor, Majid ^{[3
]}

Andleeb, Shumaila ^{[8
]}

Riaz, Romana ^{[9
]}

Munawar, Shaukat Hussain ^{[10
]}

Manzoor, Zahid ^{[10
]}

Mumtaz, Asma ^{[9
,11
]}

机构：

[1] Ocean Univ China, Sch Med & Pharm, Shandong Prov Key Lab Glycosci & Glycoengn, Qingdao 266003, Peoples R China

[2] Muhammad Inst Med & Allied Sci, Fatima Tu Zahara Dept Life Sci, Multan 60000, Pakistan

[3] Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310058, Peoples R China

[4] Times Inst Multan, Fac Pharmaceut Sci, Multan 60000, Pakistan

[5] Islamia Univ Bahawalpur, Fac Med & Allied Hlth Sci, Bahawalpur 93100, Pakistan

[6] Bahauddin Zakariya Univ, Fac Pharm, Dept Pharmacol, Multan 60800, Pakistan

[7] Islamia Univ Bahawalpur, Dept Pharmacol, Bahawalpur 63100, Pakistan

[8] Southern Punjab Inst Hlth Sci, Multan 60800, Pakistan

[9] Bahauddin Zakariya Univ, Fac Pharm, Dept Pharmaceut, Multan 60800, Pakistan

[10] Cholistan Univ Vet & Anim Sci, Dept Pharmacol & Toxicol, Bahawalpur 63100, Pakistan

[11] Multan Med & Dent Coll, Multan 60000, Pakistan

来源：

MOLECULES | 2022年 / 27卷 / 03期

关键词：

cisplatin; nephrotoxicity; reactive oxygen species; Alhagi camelorum; ANTIOXIDANT ACTIVITY; DAUCUS-CAROTA; KIDNEY; TOXICITY; INFLAMMATION; MECHANISMS; EXTRACT; STRESS; URINE; CELLS;

D O I：

10.3390/molecules27030941

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Alhagi camelorum (AC) is an old plant with a significant therapeutic value throughout Africa, Asia, and Latin America. The overuse of cisplatin (Cis > 50 mg/m(2)) is associated with observed nephrotoxicity, ototoxicity, gastrotoxicity, myelosuppression, and allergic reactions. Remedial measures are needed for the protection of nephrotoxicity against cisplatin. Thus, we investigated the nephroprotective effects of AC plant extract to prevent cisplatin-induced nephrotoxicity in albino Wistar rats. The presence of polyphenols, phenolic compounds, tannins, and saponins was revealed during phytochemical investigation, and a significantly intense antioxidant activity was recorded. There were no toxicological symptoms in the treated rats, and no anatomical, physiological, or histological abnormalities were found compared to the control rats. The results of correcting cisplatin-induced nephrotoxicity revealed that the extract has a significant ability to treat kidney damage, with most parameters returning to normal after only three weeks of therapy. It is concluded that co-administration of cisplatin with AC extract showed exceptional nephroprotective effects at a dose of 600 mg/kg for Cis-induced nephrotoxicity.

引用

页数：16

共 59 条

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