Substance use in individuals at clinical high risk of psychosis

被引:43
作者
Buchy, L. [1 ]
Cadenhead, K. S. [2 ]
Cannon, T. D. [3 ]
Cornblatt, B. A. [4 ]
McGlashan, T. H. [5 ]
Perkins, D. O. [6 ]
Seidman, L. J. [7 ,8 ]
Tsuang, M. T. [3 ]
Walker, E. F. [9 ,10 ]
Woods, S. W. [5 ]
Heinssen, R. [11 ]
Bearden, C. E. [12 ,13 ]
Mathalon, D. [14 ]
Addington, J. [1 ]
机构
[1] Univ Calgary, Dept Psychiat, Calgary, AB T2N 4Z6, Canada
[2] Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA
[3] Yale Univ, Dept Psychol, New Haven, CT 06520 USA
[4] Zucker Hillside Hosp, Dept Psychiat, Long Isl City, NY USA
[5] Yale Univ, Dept Psychiat, New Haven, CT 06520 USA
[6] Univ N Carolina, Dept Psychiat, Chapel Hill, NC USA
[7] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Dept Psychiat, Boston, MA 02215 USA
[8] Massachusetts Gen Hosp, Boston, MA 02114 USA
[9] Emory Univ, Dept Psychol, Atlanta, GA 30322 USA
[10] Emory Univ, Dept Psychiat, Atlanta, GA 30322 USA
[11] NIMH, Schizophrenia Spectrum Res Program, Div Adult Translat Res, Bethesda, MD 20892 USA
[12] Univ Calif Los Angeles, Dept Psychiat, Los Angeles, CA USA
[13] Univ Calif Los Angeles, Dept Biobehav Sci & Psychol, Los Angeles, CA USA
[14] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA
关键词
Alcohol; cannabis; prodrome; substance use; tobacco; ULTRA-HIGH-RISK; CANNABIS USE; 1ST-EPISODE PSYCHOSIS; ADULT PSYCHOSIS; SYMPTOMS; PEOPLE; IMPACT; DISORDERS; ONSET; ADOLESCENTS;
D O I
10.1017/S0033291715000227
中图分类号
B849 [应用心理学];
学科分类号
040203 ;
摘要
Background. A series of research reports has indicated that the use of substances such as cannabis, alcohol and tobacco are higher in youth at clinical high risk (CHR) of developing psychosis than in controls. Little is known about the longitudinal trajectory of substance use, and findings on the relationship between substance use and later transition to psychosis in CHR individuals are mixed. Method. At baseline and 6- and 12-month follow-ups, 735 CHR and 278 control participants completed the Alcohol and Drug Use Scale and a cannabis use questionnaire. The longitudinal trajectory of substance use was evaluated with linear mixed models. Results. CHR participants endorsed significantly higher cannabis and tobacco use severity, and lower alcohol use severity, at baseline and over a 1-year period compared with controls. CHR youth had higher lifetime prevalence and frequency of cannabis, and were significantly younger upon first use, and were more likely to use alone and during the day. Baseline substance use did not differentiate participants who later transitioned to psychosis (n = 90) from those who did not transition (n = 272). Controls had lower tobacco use than CHR participants with a prodromal progression clinical outcome and lower cannabis use than those with a psychotic clinical outcome at the 2-year assessment. Conclusions. In CHR individuals cannabis and tobacco use is higher than in controls and this pattern persists across 1 year. Evaluation of clinical outcome may provide additional information on the longitudinal impact of substance use that cannot be detected through evaluation of transition/non-transition to psychosis alone.
引用
收藏
页码:2275 / 2284
页数:10
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