Activity-based protein profiling of host-virus interactions

被引：22

作者：

Blais, David R. ^{[1
]}

Nasheri, Neda ^{[1
,2
]}

McKay, Craig S. ^{[1
,3
]}

Legault, Marc C. B. ^{[1
,3
]}

Pezacki, John Paul ^{[1
,2
,3
]}

机构：

[1] Natl Res Council Canada, Steacie Inst Mol Sci, Ottawa, ON K1A 0R6, Canada

[2] Univ Ottawa, Dept Biochem Microbiol & Immunol, Ottawa, ON K1H 8M5, Canada

[3] Univ Ottawa, Dept Chem, Ottawa, ON K1N 6N5, Canada

来源：

TRENDS IN BIOTECHNOLOGY | 2012年 / 30卷 / 02期

关键词：

UBIQUITIN-SPECIFIC PROTEASE; ACUTE RESPIRATORY SYNDROME; ACTIVITY-BASED PROBES; INFLUENZA-A VIRUS; 2-DIMENSIONAL GEL-ELECTROPHORESIS; INFECTIOUS-BRONCHITIS VIRUS; LARGE TEGUMENT PROTEIN; HEPATITIS-B-VIRUS; FUNCTIONAL PROTEOMICS; NUCLEOLAR PROTEOME;

D O I：

10.1016/j.tibtech.2011.08.001

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Virologists have benefited from large-scale profiling methods to discover new host-virus interactions and to learn about the mechanisms of pathogenesis. One such technique, referred to as activity-based protein profiling (ABPP), uses active site-directed probes to monitor the functional state of enzymes, taking into account post-translational interactions and modifications. ABPP gives insight into the catalytic activity of enzyme families that does not necessarily correlate with protein abundance. ABPP has been used to investigate several viruses and their interactions with their hosts. Differential enzymatic activity induced by viruses has been monitored using ABPP. In this review, we present recent advances and trends involving the use of ABPP methods in understanding host-virus interactions and in identifying novel targets for diagnostic and therapeutic applications.

引用

页码：89 / 99

页数：11

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