Repeatability of i.Profiler for measuring wavefront aberrations in healthy eyes

Purpose To evaluate the repeatability of wavefront aberration measurements and the correlation between corneal aberration and pupil size in normal eyes using a wavefront-based autorefractor (i.Profiler(Plus); Carl Zeiss Vision, Germany). Methods A prospective cross-sectional study. Wavefront aberrations, including spherical aberration (SA) (Z(4)(0)), coma (Z(3)(-1), Z(3)(1)), trefoil (Z(3)(-3), Z(3)(3)) and total higher-order aberrations (tHOA), were measured at different pupil diameters. The repeatability was evaluated using one-way ANOVA method, and statistical indicators including within-subject standard deviation (S-w), test-retest repeatability (TRT), and intra-class correlation coefficient (ICC). The correlations between corneal aberrations and pupil sizes were evaluated by Pearson correlation analysis. Results A total of 96 healthy young volunteers were enrolled. Corneal and ocular higher-order aberrations (HOA) measured by i.Profiler showed S-w < 0.01 mu m, TRT < 0.10 mu m, ICC > 0.90. There was a linear positive correlation between the corneal HOA and pupil size. The correlation coefficient between SA and tHOA was the largest (r = 0.996, P < 0.001). Conclusions The measurements of wavefront aberrations by i.Profiler are highly repeatable. Corneal HOA was significantly dependent on pupil size. SA was the most influential aberration for visual quality in this study.