Ensembl 2018

被引：1992

作者：

Zerbino, Daniel R. ^{[1
]}

Achuthan, Premanand ^{[1
]}

Akanni, Wasiu ^{[1
]}

Amode, M. Ridwan ^{[1
]}

Barrell, Daniel ^{[1
,2
]}

Bhai, Jyothish ^{[1
]}

Billis, Konstantinos ^{[1
]}

Cummins, Carla ^{[1
]}

Gall, Astrid ^{[1
]}

Giron, Carlos Garcia ^{[1
]}

Gil, Laurent ^{[1
]}

Gordon, Leo ^{[1
]}

Haggerty, Leanne ^{[1
]}

Haskell, Erin ^{[1
]}

Hourlier, Thibaut ^{[1
]}

Izuogu, Osagie G. ^{[1
]}

Janacek, Sophie H. ^{[1
]}

Juettemann, Thomas ^{[1
]}

To, Jimmy Kiang ^{[1
]}

Laird, Matthew R. ^{[1
]}

Lavidas, Ilias ^{[1
]}

Liu, Zhicheng ^{[1
]}

Loveland, Jane E. ^{[1
]}

Maurel, Thomas ^{[1
]}

McLaren, William ^{[1
]}

Moore, Benjamin ^{[1
]}

Mudge, Jonathan ^{[1
]}

Murphy, Daniel N. ^{[1
]}

Newman, Victoria ^{[1
]}

Nuhn, Michael ^{[1
]}

Ogeh, Denye ^{[1
]}

Ong, Chuang Kee ^{[1
]}

Parker, Anne ^{[1
]}

Patricio, Mateus ^{[1
]}

Riat, Harpreet Singh ^{[1
]}

Schuilenburg, Helen ^{[1
]}

Sheppard, Dan ^{[1
]}

Sparrow, Helen ^{[1
]}

Taylor, Kieron ^{[1
]}

Thormann, Anja ^{[1
]}

Vullo, Alessandro ^{[1
]}

Walts, Brandon ^{[1
]}

Zadissa, Amonida ^{[1
]}

Frankish, Adam ^{[1
]}

Hunt, Sarah E. ^{[1
]}

Kostadima, Myrto ^{[1
]}

Langridge, Nicholas ^{[1
]}

Martin, Fergal J. ^{[1
]}

Muffato, Matthieu ^{[1
]}

Perry, Emily ^{[1
]}

机构：

[1] European Bioinformat Inst, European Mol Biol Lab, Wellcome Genome Campus, Cambridge CB10 1SD, England

[2] Eagle Genom Ltd, Wellcome Genome Campus, Cambridge CB10 1DR, England

[3] Wellcome Trust Sanger Inst, Wellcome Genome Campus, Cambridge CB10 1SA, England

来源：

NUCLEIC ACIDS RESEARCH | 2018年 / 46卷 / D1期

基金：

欧盟地平线“2020”; 英国惠康基金; 美国国家卫生研究院; 英国生物技术与生命科学研究理事会;

关键词：

DATABASE; PROJECT; VARIANTS; ARCHIVE;

D O I：

10.1093/nar/gkx1098

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Ensembl project has been aggregating, processing, integrating and redistributing genomic datasets since the initial releases of the draft human genome, with the aim of accelerating genomics research through rapid open distribution of public data. Large amounts of rawdata are thus transformed into knowledge, which is made available via amultitude of channels, in particular our browser (http://www.ensembl.org). Over time, we have expanded in multiple directions. First, our resources describe multiple fields of genomics, in particular gene annotation, comparative genomics, genetics and epigenomics. Second, we cover a growing number of genome assemblies; Ensembl Release 90 contains exactly 100. Third, our databases feed simultaneously into an array of services designed around different use cases, ranging from quick browsing to genome-wide bioinformatic analysis. We present here the latest developments of the Ensembl project, with a focus on managing an increasing number of assemblies, supporting efforts in genome interpretation and improving our browser.

引用

页码：D754 / D761

页数：8

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