Guidelines for preclinical and early phase clinical assessment of novel radiosensitisers

被引：133

作者：

Harrington, K. J. ^{[1
,2
]}

Billingham, L. J. ^{[3
]}

Brunner, T. B. ^{[4
]}

Burnet, N. G. ^{[5
,6
]}

Chan, C. S. ^{[7
]}

Hoskin, P. ^{[8
]}

Mackay, R. I. ^{[9
]}

Maughan, T. S. ^{[10
]}

Macdougall, J. ^{[7
]}

McKenna, W. G. ^{[4
]}

Nutting, C. M. ^{[1
,2
]}

Oliver, A. ^{[7
]}

Plummer, R. ^{[11
]}

Stratford, I. J.

Illidge, T. ^{[9
,12
]}

机构：

[1] Inst Canc Res, London SW3 6JB, England

[2] Royal Marsden NHS Fdn Trust, Targeted Therapy Lab, Sect Cell & Mol Biol, Chester Beatty Labs, London SW3 6JB, England

[3] Univ Birmingham, Canc Res UK Clin Trials Unit, Birmingham, W Midlands, England

[4] Univ Oxford, Gray Inst Radiat Oncol & Biol, Oxford, England

[5] Addenbrookes Hosp, Dept Oncol, Cambridge, England

[6] Addenbrookes Hosp, Ctr Oncol, Cambridge, England

[7] Natl Inst Canc Res, London, England

[8] Mt Vernon Hosp, Northwood HA6 2RN, Middx, England

[9] Christie NHS Fdn Trust, Manchester, Lancs, England

[10] Cardiff Univ Sch Med, Velindre Hosp, Cardiff, S Glam, Wales

[11] Newcastle Univ, No Inst Canc Res, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

[12] Univ Manchester, Sch Canc Enabling Sci & Technol, Manchester, Lancs, England

来源：

BRITISH JOURNAL OF CANCER | 2011年 / 105卷 / 05期

基金：

英国医学研究理事会;

关键词：

assessment; novel radiosensitisers; early; preclinical; clinical; LOCALLY ADVANCED HEAD; SQUAMOUS-CELL CARCINOMA; CELLULARITY FOLLOWING IRRADIATION; INTENSITY-MODULATED RADIOTHERAPY; INTESTINAL CRYPT SURVIVAL; STRAND BREAK REPAIR; X-RAY EXPOSURES; NECK-CANCER; DNA-REPAIR; CONCOMITANT CHEMOTHERAPY;

D O I：

10.1038/bjc.2011.240

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

There is a growing appreciation of the potential value of combining novel molecularly-targeted drugs with radiotherapy or chemoradiotherapy. Such approaches have the potential to improve locoregional disease control and cure rates across a diverse range of tumour types. In this report, we outline a rational framework for developing novel drug-radiation combinations. In doing so, we make recommendations regarding the core preclinical data sets that are required to serve as justification for studies in humans and describe potential clinical trial designs that may be adopted by investigators.

引用

页码：628 / 639

页数：12

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