EZH2-mediated epigenetic repression of DNA repair in promoting breast tumor initiating cells

被引：19

作者：

Andri Stefansson, Olafur ^{[1
]}

Esteller, Manel ^{[1
,2
]}

机构：

[1] Bellvitge Biomed Res Inst, Canc Epigenet & Biol Program PEBC, Barcelona 08908, Catalonia, Spain

[2] Inst Catalana Recerca & Estudis Avancats, Barcelona 08010, Catalonia, Spain

来源：

BREAST CANCER RESEARCH | 2011年 / 13卷 / 03期

关键词：

SPORADIC BREAST; POLYCOMB; CANCER; EZH2; HYPERMETHYLATION; ROLES;

D O I：

10.1186/bcr2871

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Members of the Polycomb-group (PcG) family of proteins, including EZH2 (enhancer of zeste homolog 2), are involved in establishing epigenetic silencing of developmental genes in adult and embryonic stem cells, and their deregulation has been implicated in cancer. In a recent report, EZH2-mediated epigenetic repression of DNA damage repair in breast tumor initiating cells (BTICs) was identified as a mechanism that could promote expansion of BTICs, and may contribute to cancer progression.

引用

页数：2

共 17 条

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