Incidence of Sarcoma Histotypes and Molecular Subtypes in a Prospective Epidemiological Study with Central Pathology Review and Molecular Testing

被引:419
作者
Ducimetiere, Francoise [1 ]
Lurkin, Antoine [1 ]
Ranchere-Vince, Dominique [2 ]
Decouvelaere, Anne-Valerie [2 ]
Peoc'h, Michel [3 ]
Istier, Luc [4 ]
Chalabreysse, Philippe [5 ]
Muller, Christine [6 ]
Alberti, Laurent [7 ]
Bringuier, Pierre-Paul [8 ]
Scoazec, Jean-Yves [8 ]
Schott, Anne-Marie [9 ]
Bergeron, Christophe [10 ]
Cellier, Dominic [11 ]
Blay, Jean-Yves [7 ]
Ray-Coquard, Isabelle [1 ]
机构
[1] Univ Lyon, Canc Ctr Leon Berard, EA 4129, Lyon, France
[2] Univ Lyon, Canc Ctr Leon Berard, Dept Pathol, Lyon, France
[3] Univ St Etienne, Ctr Hosp Univ, Dept Pathol, St Etienne, France
[4] Pathol Lab, Pringy, France
[5] Cypath, Pathol Lab, Lyon, France
[6] Pathol Lab, Grenoble, France
[7] Univ Lyon, Canc Ctr Leon Berard, INSERM, U590, Lyon, France
[8] Univ Lyon, Hosp Civils Lyon, Hop Edouard Herriot, Dept Pathol, Lyon, France
[9] Univ Lyon, Hosp Civils Lyon, Pole IMER, Lyon, France
[10] Inst Hematol & Oncol Pediat, Dept Paediat, Lyon, France
[11] Merck Serono, Sci Relat, Lyon, France
关键词
GASTROINTESTINAL STROMAL TUMORS; SOFT-TISSUE SARCOMAS; INFORMATION-SYSTEM PROJECT; EUROPEAN CHILDREN 1978-1997; RHONE-ALPES REGION; CHILDHOOD-CANCER; INTERNATIONAL CLASSIFICATION; ALVEOLAR RHABDOMYOSARCOMA; GENE-EXPRESSION; POPULATION;
D O I
10.1371/journal.pone.0020294
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Background: The exact overall incidence of sarcoma and sarcoma subtypes is not known. The objective of the present population-based study was to determine this incidence in a European region (Rhone-Alpes) of six million inhabitants, based on a central pathological review of the cases. Methodology/Principal Findings: From March 2005 to February 2007, pathology reports and tumor blocks were prospectively collected from the 158 pathologists of the Rhone-Alpes region. All diagnosed or suspected cases of sarcoma were collected, reviewed centrally, examined for molecular alterations and classified according to the 2002 World Health Organization classification. Of the 1287 patients screened during the study period, 748 met the criteria for inclusion in the study. The overall crude and world age-standardized incidence rates were respectively 6.2 and 4.8 per 100,000/year. Incidence rates for soft tissue, visceral and bone sarcomas were respectively 3.6, 2.0 and 0.6 per 100,000. The most frequent histological subtypes were gastrointestinal stromal tumor (18%; 1.1/100,000), unclassified sarcoma (16%; 1/100,000), liposarcoma (15%; 0.9/100,000) and leiomyosarcoma (11%; 0.7/100,000). Conclusions/Significance: The observed incidence of sarcomas was higher than expected. This study is the first detailed investigation of the crude incidence of histological and molecular subtypes of sarcomas.
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页数:14
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