Exploiting Microwave-Assisted Organic Synthesis (MAOS) for Accessing Bioactive Scaffolds

被引：12
作者：
Khanna, Ashish [1 ]
Dubey, Prashant [2 ]
Sagar, Ram [1 ,3 ]
机构：
[1] Banaras Hindu Univ, Inst Sci, Dept Chem, Varanasi 221005, Uttar Pradesh, India
[2] Univ Allahabad, Ctr Mat Sci, Inst Interdisciplinary Studies IIDS, Prayagraj 211002, India
[3] Jawaharlal Nehru Univ, Sch Phys Sci, New Delhi 110067, India
来源：
CURRENT ORGANIC CHEMISTRY | 2021年 / 25卷 / 20期
关键词：
Microwave-assisted organic synthesis; bioactivity; anti-bacterial; anti-tubercular; anti-fungal; anti-viral; anti-cancer; anti-malarial; anti-leishmania; anti-inflammatory; anti-oxidant; anti-coagulant; anti-diabetic; ONE-POT SYNTHESIS; MOLECULAR DOCKING; IN-VITRO; ANTIPROLIFERATIVE ACTIVITY; STEREOSELECTIVE-SYNTHESIS; ANTIBACTERIAL ACTIVITY; BIOLOGICAL EVALUATION; 3-COMPONENT SYNTHESIS; ANTIFUNGAL ACTIVITY; ANTICANCER ACTIVITY;
D O I：
10.2174/1385272825666210531103927
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A microwave-assisted organic synthesis is an alternative approach towards the traditional way of heating to obtain desired bioactive scaffolds as a product. This method has transformed the approaches of organic synthesis, due to shorter reaction time with high product yields, modifications of selectivity, increased product purities, and simplification of work up procedures. The microwave-assisted reactions can be performed under solvent-free conditions. Thus, Microwave-Assisted Organic Synthesis (MAOS) has become the first choice for the medicinal chemist and chemical biologist to use as a tool to perform organic reactions in drug discovery and medicinal chemistry. Microwave-assisted organic synthesis specifically results in the desired products with higher selectivity and purity which may have better pharmacological properties. In this review article, we covered the literature from 2010-till to date, focusing on the use of microwave irradiation in performing organic reactions to deliver various bioactive scaffolds.
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页码：2378 / 2456
页数：79
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