TLC Analysis of Twelve Different Salts of Oxime HI-6-Reactivator of Nerve Agent Inhibited AChE

被引：0

作者：

Jun, Daniel ^{[1
]}

Stodulka, Petr ^{[1
]}

Hrabinova, Martina ^{[1
]}

Pohanka, Miroslav ^{[1
]}

Dolezal, Bohuslav ^{[2
]}

Kuca, Kamil ^{[1
]}

机构：

[1] Natl Def Univ, Fac Mil Hlth Sci, Ctr Adv Studies, Hradec Kralove 50001, Czech Republic

[2] Vakos XT As, Prague, Czech Republic

来源：

JPC-JOURNAL OF PLANAR CHROMATOGRAPHY-MODERN TLC | 2011年 / 24卷 / 02期

关键词：

TLC; HI-6; Salt; Oxime; Antidote; Reactivation; PYRIDINIUM ALDOXIMES; ACETYLCHOLINESTERASE REACTIVATORS; HI-6; DIMETHANESULFONATE; (E)-BUT-2-ENE LINKER; ANTIDOTES; PROPHYLAXIS; DICHLORIDE; DIAGNOSIS; EFFICACY;

D O I：

10.1556/JPC.24.2011.2.3

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Four thin-layer chromatographic (TLC) methods for identification of twelve bisquaternary acetylcholinesterase reactivator HI-6 salts (sulfate, chloride, acetate, bromide, phosphate, mesylate, tartrate, iodide, malonate, salicylate, maleinate, and tosylate) are described. By use of TLC, particular E and Z isomers of each salt on the oxime group were also separated. These TLC methods could be of high interest for rapid identification of each salt and for purity control.

引用

页码：105 / 107

页数：3

共 13 条

[1] TLC Analysis of Twelve Different Salts of Oxime HI-6 — Reactivator of Nerve Agent Inhibited AChE
Daniel Jun
Petr Stodulka
Martina Hrabinova
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Bohuslav Doleza
Kamil Kuca
JPC – Journal of Planar Chromatography – Modern TLC, 2011, 24 : 105 - 107
[2] Twelve different HI-6 salts and their potency to reactivate cyclosarin inhibited AChE in vitro
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[3] Discovery of a potent non-oxime reactivator of nerve agent inhibited human acetylcholinesterase
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[4] Universality of Oxime K203 for Reactivation of Nerve Agent-Inhibited AChE
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[5] Cholesterol oxime olesoxime (TRO19622) as a potential reactivator of nerve agent-inhibited cholinesterases
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Dias, J.
Marco-Contelles, J.
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FEBS OPEN BIO, 2022, 12 : 132 - 132
[6] Reactivation of nerve agent-inhibited human acetylcholinesterase by obidoxime, HI-6 and obidoxime+HI-6: Kinetic in vitro study with simulated nerve agent toxicokinetics and oxime pharmacokinetics
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TOXICOLOGY, 2016, 350 : 25 - 30
[7] REACTIVATION OF NERVE AGENT INHIBITED HUMAN ACETYLCHOLINESTERASES BY HI-6 AND OBIDOXIME
PUU, G
ARTURSSON, E
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[8] TLC analysis of intermediates arising during the preparation of oxime HI-6 dimethanesulfonate
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[9] Oxime K027: novel low-toxic candidate for the universal reactivator of nerve agent- and pesticide-inhibited acetylcholinesterase
Kuca, Kamil
Musilek, Kamil
Jun, Daniel
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JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2010, 25 (04) : 509 - 512
[10] The oxime of choice for the reactivation of human acetylcholinesterase inhibited by different organophosphates: Obidoxime, pralidoxime, HI 6 or HLo 7?
Worek, F
Backer, M
Widmann, R
Grencner, L
Heyes, G
Szinicz, L
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1997, 355 (04) : 588 - 588

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