TLC Analysis of Twelve Different Salts of Oxime HI-6-Reactivator of Nerve Agent Inhibited AChE

被引：0

作者：

Jun, Daniel ^{[1
]}

Stodulka, Petr ^{[1
]}

Hrabinova, Martina ^{[1
]}

Pohanka, Miroslav ^{[1
]}

Dolezal, Bohuslav ^{[2
]}

Kuca, Kamil ^{[1
]}

机构：

[1] Natl Def Univ, Fac Mil Hlth Sci, Ctr Adv Studies, Hradec Kralove 50001, Czech Republic

[2] Vakos XT As, Prague, Czech Republic

来源：

JPC-JOURNAL OF PLANAR CHROMATOGRAPHY-MODERN TLC | 2011年 / 24卷 / 02期

关键词：

TLC; HI-6; Salt; Oxime; Antidote; Reactivation; PYRIDINIUM ALDOXIMES; ACETYLCHOLINESTERASE REACTIVATORS; HI-6; DIMETHANESULFONATE; (E)-BUT-2-ENE LINKER; ANTIDOTES; PROPHYLAXIS; DICHLORIDE; DIAGNOSIS; EFFICACY;

D O I：

10.1556/JPC.24.2011.2.3

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Four thin-layer chromatographic (TLC) methods for identification of twelve bisquaternary acetylcholinesterase reactivator HI-6 salts (sulfate, chloride, acetate, bromide, phosphate, mesylate, tartrate, iodide, malonate, salicylate, maleinate, and tosylate) are described. By use of TLC, particular E and Z isomers of each salt on the oxime group were also separated. These TLC methods could be of high interest for rapid identification of each salt and for purity control.

引用

收藏

页码：105 / 107

页数：3

相关论文

共 29 条

[1] Unequal Efficacy of Pyridinium Oximes in Acute Organophosphate Poisoning [J].

Antonijevic, Biljana ;

Stojiljkovic, Milos P. .

CLINICAL MEDICINE & RESEARCH, 2007, 5 (01) :71-82

[2] Organophosphates/nerve agent poisoning: Mechanism of action, diagnosis, prophylaxis, and treatment [J].

Bajgar, J .

ADVANCES IN CLINICAL CHEMISTRY, VOL. 38, 2004, 38 :151-216

[3] Analysis of Pyridinium Aldoximes - A Chromatographic Approach [J].

Csermely, T. ;

Kalasz, H. ;

Petroianu, G. A. ;

Kuca, K. ;

Darvas, F. ;

Ludanyi, K. ;

Mudhafar, A. A. ;

Tekes, K. .

CURRENT MEDICINAL CHEMISTRY, 2008, 15 (23) :2401-2418

[4] TLC of quaternary pyridinium aldoximes, antidotes of organophosphorus esterase [J].

Csermely, Tamas ;

Petroianu, Georg ;

Kuca, Kamil ;

Furesz, Jozsef ;

Darvas, Ferenc ;

Gulyas, Zsolt ;

Laufer, Rudolf ;

Kalasz, Huba .

JPC-JOURNAL OF PLANAR CHROMATOGRAPHY-MODERN TLC, 2007, 20 (01) :39-42

[5] REVIEW OF OXIMES AVAILABLE FOR TREATMENT OF NERVE AGENT POISONING [J].

DAWSON, RM .

JOURNAL OF APPLIED TOXICOLOGY, 1994, 14 (05) :317-331

[6]

HAGEDORN I, 1978, Patent No. 4128651

[7]

HAGEDORN I, 1973, Patent No. 3773775

[8] TLC analysis of intermediates arising during the preparation of oxime HI-6 dimethanesulfonate [J].

Jun, Daniel ;

Stodulka, Petr ;

Kuca, Kamil ;

Koleckar, Vit ;

Dolezal, Bohuslav ;

Simon, Peter ;

Veverka, Miroslav .

JOURNAL OF CHROMATOGRAPHIC SCIENCE, 2008, 46 (04) :316-319

[9] HPLC analysis of HI-6 dichloride and dimethanesulfonate - Antidotes against nerve agents and organophosphorus pesticides [J].

Jun, Daniel ;

Kuca, Kamil ;

Stodulka, Petr ;

Koleckar, Vit ;

Dolezal, Bohuslav ;

Simon, Peter ;

Veverka, Miroslav .

ANALYTICAL LETTERS, 2007, 40 (14) :2783-2787

[10] TLC identification of benzalkonium bromide homologs [J].

Jun, Daniel ;

Stodulka, Petr ;

Koleckar, Vit ;

Kuca, Kamil .

JPC-JOURNAL OF PLANAR CHROMATOGRAPHY-MODERN TLC, 2007, 20 (04) :283-285