Update on Mineral and Bone Disorders in Chronic Kidney Disease

被引：27
作者：
Foster, Jonathan D. [1 ]
机构：
[1] Univ Penn, Dept Clin Studies, Sch Vet Med, 3900 Delancey St, Philadelphia, PA 19104 USA
来源：
VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE | 2016年 / 46卷 / 06期
关键词：
Renal secondary hyperparathyroidism; Fibroblast growth factor 23; Renal osteodystrophy; Hyperphosphatemia; CHRONIC-RENAL-FAILURE; GROWTH-FACTOR; 23; IONIZED CALCIUM CONCENTRATIONS; PLACEBO-CONTROLLED TRIAL; PARATHYROID-HORMONE; SECONDARY HYPERPARATHYROIDISM; HEMODIALYSIS-PATIENTS; PHOSPHATE BINDERS; DIALYSIS PATIENTS; SERUM PHOSPHORUS;
D O I：
10.1016/j.cvsm.2016.06.003
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
The inappropriate phosphorus retention observed in chronic kidney disease is central to the pathophysiology of mineral and bone disorders observed in these patients. Subsequent derangements in serum fibroblast growth factor 23, parathyroid hormone, and calcitriol concentrations play contributory roles. Therapeutic intervention involves dietary phosphorus restriction and intestinal phosphate binders in order to correct phosphorus retention and maintain normocalcemia. Additional therapies may be considered to normalize serum fibroblast growth factor 23 and parathyroid hormone.
引用
收藏
页码：1131 / +
页数：21
相关论文
共 74 条
[1]   Feline chronic renal failure: calcium homeostasis in 80 cases diagnosed between 1992 and 1995 [J].
Barber, PJ ;
Elliott, J .
JOURNAL OF SMALL ANIMAL PRACTICE, 1998, 39 (03) :108-116
[2]   Phosphate Transporters and Their Function [J].
Biber, Juerg ;
Hernando, Nati ;
Forster, Ian .
ANNUAL REVIEW OF PHYSIOLOGY, VOL 75, 2013, 75 :535-550
[3]   Arterial calcifications, arterial stiffness, and cardiovascular risk in end-stage renal disease [J].
Blacher, J ;
Guerin, AP ;
Pannier, B ;
Marchais, SJ ;
London, GM .
HYPERTENSION, 2001, 38 (04) :938-942
[4]   Association of serum phosphorus and calcium x phosphate product with mortality risk in chronic hemodialysis patients: A national study [J].
Block, GA ;
Hulbert-Shearon, TE ;
Levin, NW ;
Port, FK .
AMERICAN JOURNAL OF KIDNEY DISEASES, 1998, 31 (04) :607-617
[5]   A 12-Week, Double-Blind, Placebo-Controlled Trial of Ferric Citrate for the Treatment of Iron Deficiency Anemia and Reduction of Serum Phosphate in Patients With CKD Stages 3-5 [J].
Block, Geoffrey A. ;
Fishbane, Steven ;
Rodriguez, Mariano ;
Smits, Gerard ;
Shemesh, Shay ;
Pergola, Pablo E. ;
Wolf, Myles ;
Chertow, Glenn M. .
AMERICAN JOURNAL OF KIDNEY DISEASES, 2015, 65 (05) :728-736
[6]  
Borolossy El R, 2015, PEDIATR NEPHROL, V31, P1
[7]   Clinicopathological Variables Predicting Progression of Azotemia in Cats with Chronic Kidney Disease [J].
Chakrabarti, S. ;
Syme, H. M. ;
Elliott, J. .
JOURNAL OF VETERINARY INTERNAL MEDICINE, 2012, 26 (02) :275-281
[8]   Sevelamer carbonate lowers serum phosphorus effectively in haemodialysis patients: a randomized, double-blind, placebo-controlled, dose-titration study [J].
Chen, Nan ;
Wu, Xiongfei ;
Ding, Xiaoqiang ;
Mei, Changlin ;
Fu, Ping ;
Jiang, Gengru ;
Li, Xuemei ;
Chen, Jianghua ;
Liu, Bicheng ;
La, Yan ;
Hou, Fanfan ;
Ni, Zhaohui ;
Fu, Junzhou ;
Xing, Changying ;
Yu, Xuequing ;
Huang, Chaoxing ;
Zuo, Li ;
Wang, Li ;
Hunter, John ;
Dillon, Maureen ;
Plone, Melissa ;
Neylan, John .
NEPHROLOGY DIALYSIS TRANSPLANTATION, 2014, 29 (01) :152-160
[9]   A randomized, double-blind, placebo-controlled trial of niacinamide for reduction of phosphorus in hemodialysis patients [J].
Cheng, Steven C. ;
Young, Daniel O. ;
Huang, Yihung ;
Delmez, James A. ;
Coyne, Daniel W. .
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2008, 3 (04) :1131-1138
[10]   Effect of Cinacalcet on Cardiovascular Disease in Patients Undergoing Dialysis [J].
Chertow, Glenn M. ;
Block, Geoffrey A. ;
Correa-Rotter, Ricardo ;
Drueeke, Tilman B. ;
Floege, Juergen ;
Goodman, William G. ;
Herzog, Charles A. ;
Kubo, Yumi ;
London, Gerard M. ;
Mahaffey, Kenneth W. ;
Mix, T. Christian H. ;
Moe, Sharon M. ;
Trotman, Marie-Louise ;
Wheeler, David C. ;
Parfrey, Patrick S. .
NEW ENGLAND JOURNAL OF MEDICINE, 2012, 367 (26) :2482-2494
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