RADIOTHERAPY IN SMALL-CELL LUNG CANCER: LESSONS LEARNED AND FUTURE DIRECTIONS

被引:26
作者
Slotman, Ben J. [1 ]
Senan, Suresh [1 ]
机构
[1] Vrije Univ Amsterdam Med Ctr, Dept Radiat Oncol, NL-1081 HV Amsterdam, Netherlands
来源
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | 2011年 / 79卷 / 04期
关键词
Small-cell lung cancer; Prophylactic Cranial irradiation; Thoracic radiotherapy; PROPHYLACTIC CRANIAL IRRADIATION; COMBINED-MODALITY TREATMENT; THORACIC RADIATION-THERAPY; PHASE-II TRIAL; CONCURRENT CHEMOTHERAPY; COMPLETE REMISSION; BRAIN METASTASES; RANDOMIZED-TRIAL; CARCINOMA; ETOPOSIDE;
D O I
10.1016/j.ijrobp.2010.10.039
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Although chemotherapy is an essential component in the treatment of small-cell lung cancer, improvements in survival in the past two decades have been mainly achieved by the appropriate application of radiotherapy. The aim of the present study was to review the key developments in thoracic radiotherapy and prophylactic cranial radiotherapy and to discuss the rationale behind key ongoing studies in small-cell lung cancer. (C) 2011 Elsevier Inc.
引用
收藏
页码:998 / 1003
页数:6
相关论文
共 44 条
[1]   PROPHYLACTIC CRANIAL IRRADIATION FOR PATIENTS WITH SMALL-CELL LUNG-CANCER IN COMPLETE REMISSION [J].
ARRIAGADA, R ;
LECHEVALIER, T ;
BORIE, F ;
RIVIERE, A ;
CHOMY, P ;
MONNET, I ;
TARDIVON, A ;
VIADER, F ;
TARAYRE, M ;
BENHAMOU, S .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1995, 87 (03) :183-190
[2]   Prophylactic cranial irradiation for patients with small-cell lung cancer in complete remission [J].
Aupérin, A ;
Arriagada, R ;
Pignon, JP ;
Le Péchoux, C ;
Gregor, A ;
Stephens, RJ ;
Kristjansen, PEG ;
Johnson, BE ;
Ueoka, H ;
Wagner, H ;
Aisner, J .
NEW ENGLAND JOURNAL OF MEDICINE, 1999, 341 (07) :476-484
[3]   Concurrent chemotherapy (carboplatin, paclitaxel, etoposide) and involved-field radiotherapy in limited stage small cell lung cancer: a Dutch multicenter phase II study [J].
Baas, P ;
Belderbos, JSA ;
Senan, S ;
Kwa, HB ;
van Bochove, A ;
van Tinteren, H ;
Burgers, JA ;
van Meerbeeck, J .
BRITISH JOURNAL OF CANCER, 2006, 94 (05) :625-630
[4]   70 GY thoracic radiotherapy is feasible concurrent with chemotherapy for limited-stage small-cell lung cancer: Analysis of cancer and leukemia group B study 39808 [J].
Bogart, JA ;
Herndon, JE ;
Lyss, AP ;
Watson, D ;
Miller, AA ;
Lee, ME ;
Turrisi, AT ;
Green, MR .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2004, 59 (02) :460-468
[5]   Phase III comparison of twice-daily split-course irradiation versus once-daily irradiation for patients with limited stage small-cell lung carcinoma [J].
Bonner, JA ;
Sloan, JA ;
Shanahan, TG ;
Brooks, BJ ;
Marks, RS ;
Krook, JE ;
Gerstner, JB ;
Maksymiuk, A ;
Levitt, R ;
Mailliard, JA ;
Tazelaar, HD ;
Hillman, S ;
Jett, JR .
JOURNAL OF CLINICAL ONCOLOGY, 1999, 17 (09) :2681-2691
[6]  
BUNN PA, 1981, LUNG CANCER, P169
[7]  
CARNEY DN, 1983, CANCER RES, V43, P2806
[8]   Phase I study to determine the maximum-tolerated dose of radiation in standard daily and hyperfractionated-accelerated twice-daily radiation schedules with concurrent chemotherapy for limited-stage small-cell lung cancer [J].
Choi, NC ;
Herndon, JE ;
Rosenman, J ;
Carey, RW ;
Chung, CT ;
Bernard, S ;
Leone, L ;
Seagren, S ;
Green, M .
JOURNAL OF CLINICAL ONCOLOGY, 1998, 16 (11) :3528-3536
[9]   Time between the first day of chemotherapy and the last day of chest radiation is the most important predictor of survival in limited-disease small-cell lung cancer [J].
De Ruysscher, D ;
Pijls-Johannesma, M ;
Bentzen, SM ;
Minken, A ;
Wanders, R ;
Lutgens, L ;
Hochstenbag, M ;
Boersma, L ;
Wouters, B ;
Lammering, G ;
Vansteenkiste, J ;
Lambin, P .
JOURNAL OF CLINICAL ONCOLOGY, 2006, 24 (07) :1057-1063
[10]   Omission of elective node irradiation on basis of CT-scans in patients with limited disease small cell lung cancer: A phase II trial [J].
De Ruysscher, Dirk ;
Bremer, Robert-Harm ;
Koppe, Friederike ;
Wanders, Stofferinus ;
van Haren, Erik ;
Hochstenbag, Monique ;
Geeraedts, Wiel ;
Pitz, Cordula ;
Simons, Jean ;
ten Velde, Guul ;
Dohmen, Jo ;
Snoep, Gabriel ;
Boersma, Liesbeth ;
Verschueren, Tom ;
van Baardwijk, Angela ;
Dehing, Cary ;
Pijls, Madelon ;
Minken, Andre ;
Lambin, Philippe .
RADIOTHERAPY AND ONCOLOGY, 2006, 80 (03) :307-312