Muscarinic receptor agonists and antagonists

被引：69
作者：
Broadley, KJ
Kelly, DR
机构：
[1] Cardiff Univ, Welsh Sch Pharm, Div Pharmacol, Cardiff CF10 3TB, S Glam, Wales
[2] Cardiff Univ, Dept Chem, Cardiff CF10 3TB, S Glam, Wales
来源：
MOLECULES | 2001年 / 6卷 / 03期
关键词：
Alzheimer's disease; nicotine; acetylcholine; arecoline; himbacine; tacrine; cyclostelletamines; intramolecular Diels-Alder reaction; indole alkaloids;
D O I：
10.3390/60300142
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A comprehensive review of pharmacological and medical aspects of the muscarinic class of acetylcholine agonists and antagonists is presented. The therapeutic benefits of achieving receptor subtype selectivity are outlined and applications in the treatment of Alzheimer's disease are discussed. A selection of chemical routes are described, which illustrate contemporary methodology for the synthesis of chiral medicinal compounds (asymmetric synthesis, chiral pool, enzymes). Routes to bicyclic intrannular amines and intramolecular Diels-Alder reactions are highlighted.
引用
收藏
页码：142 / 193
页数：52
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