Autophagy, inflammation and neurodegenerative disease

被引：77

作者：

Alirezaei, Mehrdad ^{[1
]}

Kemball, Christopher C. ^{[1
]}

Whitton, J. Lindsay ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Immunol & Microbial Sci, La Jolla, CA 92037 USA

来源：

EUROPEAN JOURNAL OF NEUROSCIENCE | 2011年 / 33卷 / 02期

关键词：

autophagy; fasting; HIV; multiple sclerosis; neuroinflammation; CENTRAL-NERVOUS-SYSTEM; MULTIPLE-SCLEROSIS; TRANSGENIC MICE; B-CELLS; AUTOIMMUNE ENCEPHALOMYELITIS; THERAPEUTIC TARGETS; NEURONAL AUTOPHAGY; SELF-DIGESTION; GLIAL-CELLS; MOUSE MODEL;

D O I：

10.1111/j.1460-9568.2010.07500.x

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Autophagy is emerging as a central regulator of cellular health and disease and, in the central nervous system (CNS), this homeostatic process appears to influence synaptic growth and plasticity. Herein, we review the evidence that dysregulation of autophagy may contribute to several neurodegenerative diseases of the CNS. Up-regulation of autophagy may prevent, delay or ameliorate at least some of these disorders, and - based on recent findings from our laboratory - we speculate that this goal may be achieved using a safe, simple and inexpensive approach.

引用

页码：197 / 204

页数：8

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