Clec14a is specifically expressed in endothelial cells and mediates cell to cell adhesion

被引：42

作者：

Rho, Seung-Sik ^{[1
]}

Choi, Hyun-Jung ^{[1
]}

Min, Jeong-Ki ^{[2
]}

Lee, Heon-Woo ^{[1
]}

Park, Hongryeol ^{[1
]}

Park, Hyojin ^{[1
]}

Kim, Young-Myeong ^{[3
]}

Kwon, Young-Guen ^{[1
]}

机构：

[1] Yonsei Univ, Coll Life Sci & Biotechnol, Dept Biochem, Seoul 120749, South Korea

[2] Korea Res Inst Biosci & Biotechnol, Therapeut Antibody Res Ctr, Taejon, South Korea

[3] Kangwon Natl Univ, Dept Mol & Cellular Biochem, Chunchon, South Korea

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2011年 / 404卷 / 01期

关键词：

Clec14a; C-type lectin like domain; Endothelial cell; Cell-cell adhesion; Angiogenesis; LECTIN-LIKE DOMAIN; TISSUE; ENDOSIALIN; PROTOCOL; ANTIGEN; C1QRP; CD93;

D O I：

10.1016/j.bbrc.2010.11.075

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Clec14a is a member of the thrombomodulin (TM) family, but its function has not yet been determined. Here, we report that Clec14a is a plasma membrane protein of endothelial cells (ECs) expressed specifically in the vasculature of mice. Deletion mutant analysis revealed that Clec14a mediates cell-cell adhesion through its C-type lectin-like domain. Knockdown of Clec14a in ECs suppressed cell migratory activity and filopodial protrusion, and delayed formation of tube-like structures. These findings demonstrate that Clec14a is a novel EC-specific protein that appears to play a role in cell-cell adhesion and angiogenesis. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：103 / 108

页数：6

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