FGF signaling in the developing endochondral skeleton

被引：279
作者：
Ornitz, DM [1 ]
机构：
[1] Washington Univ, Sch Med, Dept Mol Biol & Pharmacol, St Louis, MO 63110 USA
来源：
CYTOKINE & GROWTH FACTOR REVIEWS | 2005年 / 16卷 / 02期
关键词：
FGF; skeletal development; craniosynostosis; achondroplasia; receptor tyrosine kinase;
D O I：
10.1016/j.cytogfr.2005.02.003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Mutations in fibroblast growth factor receptors (Fgfrs) are the etiology of many craniosynostosis and chondrodysplasia syndromes in humans. The phenotypes associated with these human syndromes and the phenotypes resulting from targeted mutagenesis in the mouse have defined essential roles for FGF signaling in both endochondral and intramembranous bone development. In this review, I will focus on the role of FGF signaling in chondrocytes and osteoblasts and how FGFs regulate the growth and development of endochondral bone. (c) 2005 Elsevier Ltd. All rights reserved.
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收藏
页码：205 / 213
页数：9
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