A case of osteoclastic variant of anaplastic thyroid carcinoma: Diagnostic and prognostic marker studies by cytology

被引：0

作者：

Bantumilli, Surekha ^{[1
]}

Zhu, Lee-Ching ^{[1
]}

Sakthivel, Muthukumar ^{[2
]}

Dodd, Leslie ^{[1
]}

机构：

[1] Univ N Carolina, Dept Pathol & Lab Med, 160 North Med Dr,CB 7525, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Dept Radiol, Chapel Hill, NC 27599 USA

来源：

DIAGNOSTIC CYTOPATHOLOGY | 2022年 / 50卷 / 12期

关键词：

anaplastic carcinoma; cytology diagnosis of thyroid carcinoma; osteoclastic variant; osteoclast-like giant cells; PD-L1 in thyroid carcinoma;

D O I：

10.1002/dc.25028

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Anaplastic thyroid carcinoma is an infrequent, but aggressive fatal subtype of thyroid cancer. The osteoclastic variant of anaplastic carcinoma is a rare subtype of anaplastic carcinoma with rare cases reported in the literature. Molecular targeted therapies have emerged for the anaplastic carcinoma, necessitating accurate pathologic diagnosis with additional ancillary testing for directing clinical management. We present here the cytological diagnosis of an anaplastic thyroid carcinoma-osteoclastic variant on fine-needle aspiration (FNA), with emphasis on the novelty of utilizing the least invasive procedure (aspiration cytology) for rendering pathological diagnosis as well as identifying potential prognostic markers for targeted immunotherapy.

引用

页码：E357 / E360

页数：4