International multicentre retrospective cohort study of ocular adnexal marginal zone B-cell lymphoma

被引:37
作者
Hindso, Tine Gadegaard [1 ]
Esmaeli, Bita [2 ]
Holm, Frederik [3 ]
Mikkelsen, Lauge Hjorth [1 ,3 ]
Rasmussen, Peter Kristian [1 ]
Coupland, Sarah E. [4 ]
Finger, Paul T. [5 ]
Graue, Gerardo F. [5 ]
Grossniklaus, Hans E. [6 ]
Honavar, Santosh G. [7 ]
Khong, Jwu Jin [8 ]
McKelvie, Penelope A. [9 ]
Mulay, Kaustubh [10 ]
Sjo, Lene Dissing [3 ]
Vemuganti, Geeta K. [11 ]
Thuro, Bradley A. [2 ]
Heegaard, Steffen [1 ,3 ]
机构
[1] Rigshosp Glostrup, Dept Ophthalmol, DK-2100 Glostrup, Denmark
[2] Univ Texas MD Anderson Canc Ctr, Orbital Oncol & Ophthalm Plast Surg, Dept Plast Surg, Houston, TX 77030 USA
[3] Rigshosp, Dept Pathol, Copenhagen, Denmark
[4] Univ Liverpool, Dept Clin & Canc Med, Liverpool, Merseyside, England
[5] New York Eye Canc Ctr, Ophthalm Oncol, New York, NY USA
[6] Emory Univ, Eye Ctr, Sect Ocular Oncol, Atlanta, GA 30322 USA
[7] LV Prasad Eye Inst, Dept Ocular Oncol & Oculoplast, Hyderabad, India
[8] Royal Victorian Eye & Ear Hosp, Orbital Plast & Lacrimal Unit, Melbourne, Vic, Australia
[9] St Vincents Hosp, Dept Anat Pathol, Melbourne, Vic, Australia
[10] Natl Reporting Ctr Ophthalm Pathol, Ctr Sight, Ophthalm Pathol, Hyderabad, India
[11] Univ Hyderabad, Sch Med Sci, Kallam Anji Reddy Campus, Hyderabad, India
关键词
CHLAMYDIA-PSITTACI; NO EVIDENCE; ASSOCIATION; DIAGNOSIS; REGION; TISSUE; ORBIT;
D O I
10.1136/bjophthalmol-2019-314008
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Backgrounds/aims To date, this is the largest cohort study on extranodal marginal zone B-cell lymphoma (EMZL) of the ocular adnexa (OA). The aim of the study was to characterise the clinical features of OA-EMZL. Methods A retrospective multicentre study involving seven international eye cancer centres. Data were collected from 1 January 1980 through 31 December 2017. A total of 689 patients with OA-EMZL were included. Results The median follow-up time was 42 months. The median age was 62 years (range, 8-100 years), and 55 % (378/689 patients) of patients were women. The majority of patients (82%, 558/680 patients) were diagnosed with primary OA-EMZL with Ann Arbor stage IE (90%, 485/541 patients) and American Joint Committee on Cancer stage T2 (61%, 340/557 patients) at the time of diagnosis. The orbit (66%, 452/689 patients) and the conjunctiva (37%, 255/689 patients) were the most frequently involved anatomical structures. The 5-year, 10-year and 20-year disease-specific survival (DSS) were 96%, 91% and 90%, respectively. Stage IE patients treated with external beam radiation therapy (EBRT) as monotherapy (10-year DSS, 95%) were found to have a better DSS than stage IE patients treated with chemotherapy (10-year DSS, 86%). Stage IIIE/IVE patients treated with chemotherapy and rituximab had a better DSS (10-year DSS, 96%) than stage IIIE/IVE patients treated with chemotherapy without rituximab (10-year DSS, 63%). Conclusions and relevance EMZL is a slow-growing tumour with an excellent long-term survival. Low-dose EBRT as monotherapy should be considered in localised OA-EMZL. Rituximab-based chemotherapy should be chosen in those patients with disseminated disease.
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收藏
页码:357 / 362
页数:6
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