Binding of Pramipexole to Extrastriatal Dopamine D2/D3 Receptors in the Human Brain: A Positron Emission Tomography Study Using 11C-FLB 457

被引：19
作者：
Ishibashi, Kenji [1 ,2 ]
Ishii, Kenji [1 ]
Oda, Keiichi [1 ]
Mizusawa, Hidehiro [2 ]
Ishiwata, Kiichi [1 ]
机构：
[1] Tokyo Metropolitan Inst Gerontol, Positron Med Ctr, Tokyo, Japan
[2] Tokyo Med & Dent Univ, Dept Neurol & Neurol Sci, Grad Sch, Tokyo, Japan
来源：
PLOS ONE | 2011年 / 6卷 / 03期
基金：
日本学术振兴会;
关键词：
TREATMENT-RESISTANT DEPRESSION; NONHUMAN PRIMATE BRAIN; BIPOLAR-II DEPRESSION; PARKINSONS-DISEASE; ANTERIOR-PITUITARY; AFFINITY STATES; HUMAN FOREBRAIN; PARALLEL-GROUP; MESSENGER-RNA; D-3; RECEPTORS;
D O I：
10.1371/journal.pone.0017723
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The purpose of this study was to determine the binding sites of pramipexole in extrastriatal dopaminergic regions because its antidepressive effects have been speculated to occur by activating the dopamine D-2 receptor subfamily in extrastriatal areas. Dynamic positron emission tomography (PET) scanning using C-11-FLB 457 for quantification of D-2/D-3 receptor subtype was performed on 15 healthy volunteers. Each subject underwent two PET scans before and after receiving a single dose of pramipexole (0, 0.125, or 0.25 mg). The study demonstrated that pramipexole significantly binds to D-2/D-3 receptors in the prefrontal cortex, amygdala, and medial and lateral thalamus at a dose of 0.25 mg. These regions have been indicated to have some relation to depression and may be part of the target sites where pramipexole exerts its antidepressive effects.
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页数：6
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