Cell-type-specific inhibition of the dendritic plateau potential in striatal spiny projection neurons

被引:41
作者
Du, Kai [1 ,2 ]
Wu, Yu-Wei [3 ,4 ]
Lindroos, Robert [1 ,2 ]
Liu, Yu [3 ,4 ]
Rozsa, Balazs [5 ]
Katona, Gergely [6 ]
Ding, Jun B. [3 ,4 ]
Kotaleski, Jeanette Hellgren [1 ,2 ,7 ]
机构
[1] Karolinska Inst, Stockholm Brain Inst, S-17177 Solna, Sweden
[2] Karolinska Inst, Dept Neurosci, S-17177 Solna, Sweden
[3] Stanford Univ, Sch Med, Dept Neurosurg, Stanford, CA 94305 USA
[4] Stanford Univ, Sch Med, Dept Neurol & Neurol Sci, Stanford, CA 94305 USA
[5] Hungarian Acad Sci, Inst Expt Med, Lab Funct Imaging Neuronal Networks & Dendrit Int, H-1083 Budapest, Hungary
[6] Pazmany Peter Univ, Informacios Technol Kar Nemzeti Agykutatas Progra, Photon Measurement Technol Res Grp 2, Magyar Tudomanyos Akad Pazmany Peter Katolikus Eg, H-1088 Budapest, Hungary
[7] KTH Royal Inst Technol, Sch Comp Sci & Commun, Sci Life Lab, S-11428 Stockholm, Sweden
基金
瑞典研究理事会; 欧盟地平线“2020”;
关键词
dendritic computation; inhibition; plateau potential; synaptic integration; striatum; BASAL GANGLIA; IN-VIVO; GABAERGIC INTERNEURONS; SYNAPTIC-TRANSMISSION; NUCLEUS-ACCUMBENS; STATE TRANSITIONS; PYRAMIDAL NEURONS; RAT NEOSTRIATUM; MOTOR CONTROL; NMDA SPIKES;
D O I
10.1073/pnas.1704893114
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Striatal spiny projection neurons (SPNs) receive convergent excitatory synaptic inputs from the cortex and thalamus. Activation of spatially clustered and temporally synchronized excitatory inputs at the distal dendrites could trigger plateau potentials in SPNs. Such supralinear synaptic integration is crucial for dendritic computation. However, how plateau potentials interact with subsequent excitatory and inhibitory synaptic inputs remains unknown. By combining computational simulation, two-photon imaging, optogenetics, and dual-color uncaging of glutamate and GABA, we demonstrate that plateau potentials can broaden the spatiotemporal window for integrating excitatory inputs and promote spiking. The temporal window of spiking can be delicately controlled by GABAergic inhibition in a cell-type- specific manner. This subtle inhibitory control of plateau potential depends on the location and kinetics of the GABAergic inputs and is achieved by the balance between relief and reestablishment of NMDA receptor Mg2+ block. These findings represent a mechanism for controlling spatiotemporal synaptic integration in SPNs.
引用
收藏
页码:E7612 / E7621
页数:10
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