DRUG DISCOVERY How melanomas bypass new therapy

被引：38
作者：
Solit, David [1 ]
Sawyers, Charles L. [1 ]
机构：
[1] Mem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10065 USA
来源：
NATURE | 2010年 / 468卷 / 7326期
关键词：
CHRONIC MYELOID-LEUKEMIA; BRAF; INHIBITION; RESISTANCE; IMATINIB; CANCER; CRAF; RAF;
D O I：
10.1038/468902a
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The promise of an exciting new drug that inhibits the mutant B-RAF protein in skin cancer is marred by the fact that most patients relapse within a year. Fresh data hint at how such resistance emerges. See Lettersp.968 & p.973
引用
收藏
页码：902 / 903
页数：2
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