DRUG DISCOVERY How melanomas bypass new therapy

被引：38

作者：

Solit, David ^{[1
]}

Sawyers, Charles L. ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10065 USA

来源：

NATURE | 2010年 / 468卷 / 7326期

关键词：

CHRONIC MYELOID-LEUKEMIA; BRAF; INHIBITION; RESISTANCE; IMATINIB; CANCER; CRAF; RAF;

D O I：

10.1038/468902a

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The promise of an exciting new drug that inhibits the mutant B-RAF protein in skin cancer is marred by the fact that most patients relapse within a year. Fresh data hint at how such resistance emerges. See Lettersp.968 & p.973

引用

页码：902 / 903

页数：2

共 50 条

[21] Drug discovery in academic institutions
Frye, Stephen V.
HEMATOLOGY-AMERICAN SOCIETY OF HEMATOLOGY EDUCATION PROGRAM, 2013, : 300 - 305
[22] Drug Discovery Targeting an Amino Acid Transporter for Diagnosis and Therapy
Wiriyasermkul, Pattama
Moriyama, Satomi
Kongpracha, Pornparn
Nagamori, Shushi
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 2021, 141 (04): : 501 - 510
[23] New methodological approaches to atrial fibrillation drug discovery
Wong, Chun-Ka
Tse, Hung-Fat
EXPERT OPINION ON DRUG DISCOVERY, 2021, 16 (03) : 319 - 329
[24] GPCR drug discovery: new agents, targets and indications
Lorente, Javier Sanchez
Sokolov, Aleksandr V.
Ferguson, Gavin
Schioth, Helgi B.
Hauser, Alexander S.
Gloriam, David E.
NATURE REVIEWS DRUG DISCOVERY, 2025, : 458 - 479
[25] The Akt-like kinase of Leishmania panamensis: As a new molecular target for drug discovery
Tirado-Duarte, Didier
Marin-Villa, Marcel
Ochoa, Rodrigo
Blandon-Fuentes, Gustavo
Soares, Maurilio Jose
Maria Robledo, Sara
Varela-Miranda, Ruben E.
ACTA TROPICA, 2018, 177 : 171 - 178
[26] Patient-derived tumor xenograft models for melanoma drug discovery
Harris, Antoneicka L.
Joseph, Richard W.
Copland, John A.
EXPERT OPINION ON DRUG DISCOVERY, 2016, 11 (09) : 895 - 906
[27] Characteristics of Brazilian melanomas: real-world results before and after the introduction of new therapies
Modes da Costa, Leticia Maria
Crovador, Camila de Souza
Barbosa de Carvalho, Carlos Eduardo
Vazquez, Vinicius de Lima
BMC RESEARCH NOTES, 2019, 12 (1)
[28] Systems approaches to polypharmacology and drug discovery
Boran, Aislyn D. W.
Iyengar, Ravi
CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT, 2010, 13 (03) : 297 - 309
[29] Targeted Therapy for Melanomas Without BRAF V600 Mutations
Christian Menzer
Jessica C. Hassel
Current Treatment Options in Oncology, 2022, 23 : 831 - 842
[30] Targeted Therapy for Melanomas Without BRAF V600 Mutations
Menzer, Christian
Hassel, Jessica C.
CURRENT TREATMENT OPTIONS IN ONCOLOGY, 2022, 23 (06) : 831 - 842

← 1 2 3 4 5 →