DRUG DISCOVERY How melanomas bypass new therapy

被引：38

作者：

Solit, David ^{[1
]}

Sawyers, Charles L. ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10065 USA

来源：

NATURE | 2010年 / 468卷 / 7326期

关键词：

CHRONIC MYELOID-LEUKEMIA; BRAF; INHIBITION; RESISTANCE; IMATINIB; CANCER; CRAF; RAF;

D O I：

10.1038/468902a

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The promise of an exciting new drug that inhibits the mutant B-RAF protein in skin cancer is marred by the fact that most patients relapse within a year. Fresh data hint at how such resistance emerges. See Lettersp.968 & p.973

引用

页码：902 / 903

页数：2

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