Synthesis and antimicrobial evaluation of some fused heterocyclic [1,2,4]triazolo [3,4-b][1,3,4]thiadiazole derivatives

被引：81

作者：

Almajan, Gabriela Laura ^{[1
]}

Barbuceanu, Stefania-Felicia ^{[1
]}

Bancescu, Gabriela ^{[2
]}

Saramet, Ioana ^{[1
]}

Saramet, Gabriel ^{[3
]}

Draghici, Constantin ^{[4
]}

机构：

[1] Fac Pharm, Dept Organ Chem, Bucharest 020956, Romania

[2] Fac Dent, Dept Microbiol, Bucharest 050051, Romania

[3] Fac Pharm, Pharmaceut Tech & Drug Ind Dept, Bucharest 020956, Romania

[4] Romanian Acad, CD Nenitescu Inst Organ Chem, Bucharest 060023, Romania

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2010年 / 45卷 / 12期

关键词：

1,2,4]triazolo[3,4-b][1,3,4]thiadiazole; Cyclization; Diphenylsulfone moiety; Antimicrobial activity; ANTICONVULSANT; PRODUCTS;

D O I：

10.1016/j.ejmech.2010.10.007

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of fused 1,2,4-triazoles with diphenylsulfone moiety are prepared utilizing 4-amino-5-[4-(4-X-phenylsulfonyl)phenyl]-4H-1,2,4-triazole-3-thiol 1 (X = H, Br). The latter on reaction with aromatic isothiocyanate in DMF, aromatic acid in POCI3 and CDI in dioxane gives five membered fused triazole derivatives 2a-c, 3a-c, 4a-g, 5a-g and 6a,b. The structures of newly synthesized compounds were confirmed on the basis of their elemental analysis and spectral data results (IR, H-1-and C-13 NMR). New synthesized compounds were screened for their antimicrobial activities. The preliminary results revealed that some of the compounds exhibited promising antimicrobial activities. (C) 2010 Elsevier Masson SAS. All rights reserved.

引用

页码：6139 / 6146

页数：8

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