Phloroglucinol Benzophenones and Xanthones from the Leaves of Garcinia cowa and Their Nitric Oxide Production and α-Glucosidase Inhibitory Activities

被引：27

作者：

Raksat, Achara ^{[1
,2
]}

Phukhatmuen, Piyaporn ^{[1
,2
]}

Yang, Jianxiong ^{[5
]}

Maneerat, Wisanu ^{[1
,2
]}

Charoensup, Rawiwan ^{[3
,4
]}

Andersen, Raymond J. ^{[5
,6
]}

Wang, Yan A. ^{[5
]}

Pyne, Stephen G. ^{[7
]}

Laphookhieo, Surat ^{[1
,2
]}

机构：

[1] Mae Fah Luang Univ, Ctr Chem Innovat Sustainabil CIS, Chiang Rai 57100, Thailand

[2] Mae Fah Luang Univ, Sch Sci, Chiang Rai 57100, Thailand

[3] Mae Fah Luang Univ, Ctr Excellence Med Plants & Thai Tradit Med, Chiang Rai 57100, Thailand

[4] Mae Fah Luang Univ, Sch Integrat Med, Chiang Rai 57100, Thailand

[5] Univ British Columbia, Dept Chem, 2036 Main Mall, Vancouver, BC V6T 1Z1, Canada

[6] Univ British Columbia, Dept Earth Ocean & Atmospher Sci, 2036 Main Mall, Vancouver, BC V6T 1Z1, Canada

[7] Univ Wollongong, Sch Chem & Mol Biosci, Wollongong, NSW 2522, Australia

来源：

JOURNAL OF NATURAL PRODUCTS | 2020年 / 83卷 / 01期

关键词：

BIOACTIVE PRENYLATED XANTHONES; TETRAOXYGENATED XANTHONES; DERIVATIVES; FRUITS;

D O I：

10.1021/acs.jnatprod.9b00849

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Five new compounds-two phloroglucinol benzophenones, garciniacowones F (1) and G (2), and three xanthones, garciniacowones H (3), I (4), and J (5)-together with seven known xanthones (6-12) were isolated from the fresh leaves of Garcinia cowa. Their structures were elucidated by detailed analysis of NMR and MS data. Compounds 1 and 2 are phloroglucinol benzophenones containing a polyprenylated bicyclo[3.3.1]nonane ring system, while compounds 3-5 are rare xanthones having farnesyl (3 and 5) and geranylgeranyl (5) units at C-8. Compounds 1, 3, 4, 7, 8, and 10 exhibited inhibitory effects on NO production in LPS-induced RAW264.7 macrophage cells with IC50 values ranging from 5.4 to 18.6 mu M. Compounds 4 and 8 had alpha-glucosidase inhibitory activities with IC50 values of 15.4 and 11.4 mu M, respectively, which were more potent than that of the acarbose control.

引用

页码：164 / 168

页数：5

共 26 条

[1] A XANTHONE FROM PERICARPS OF GARCINIA-MANGOSTANA [J].