Nickel-Catalyzed Oxidative Decarboxylative (Hetero)Arylation of Unactivated C-H Bonds: Ni and Ag Synergy

被引：50

作者：

Honeycutt, Aaron P. ^{[1
]}

Hoover, Jessica M. ^{[1
]}

机构：

[1] West Virginia Univ, C Eugene Bennett Dept Chem, Morgantown, WV 26506 USA

来源：

ACS CATALYSIS | 2017年 / 7卷 / 07期

关键词：

decarboxylation; C-H activation; nickel; silver; heteroaryl; AROMATIC CARBOXYLIC-ACIDS; ORTHO-NITROBENZOIC ACIDS; BENZOIC-ACIDS; RADICAL CONDITIONS; DIRECT ARYLATION; DIRECTING GROUPS; BIARYL SYNTHESIS; ARYL HALIDES; COPPER; PROTODECARBOXYLATION;

D O I：

10.1021/acscatal.7b01683

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Oxidative decarboxylative arylation reactions are potentially attractive routes to generate biaryl structures from simple and readily available precursors; yet, they are underutilized, because of limitations in the carboxylic acid scope. Here, we report a nickel catalyst system that enables the selective decarboxylative arylation of unactivated C-H bonds with a broad scope of (hetero)aromatic carboxylate coupling partners. Preliminary mechanistic insights suggest that the efficiency and selectivity of this protocol originate from cooperation between Ni and Ag.

引用

页码：4597 / 4601

页数：5

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