Non-Canonical Helical Structure of Nucleic Acids Containing Base-Modified Nucleotides

被引：13

作者：

Balasubramaniyam, Thananjeyan ^{[1
,2
]}

Oh, Kwnag-Im ^{[1
,2
]}

Jin, Ho-Seong ^{[1
]}

Ahn, Hye-Bin ^{[1
]}

Kim, Byeong-Seon ^{[2
,3
]}

Lee, Joon-Hwa ^{[1
,2
]}

机构：

[1] Gyeongsang Natl Univ, Dept Chem, Jinju 52828, Gyeongnam, South Korea

[2] Gyeongsang Natl Univ, Res Inst Nat Sci, Jinju 52828, Gyeongnam, South Korea

[3] Gyeongsang Natl Univ, Dept Chem Educ, Jinju 52828, Gyeongnam, South Korea

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 17期

基金：

新加坡国家研究基金会;

关键词：

C8-modification; C5-modification; methylation; bromination; arylation; Z-DNA; G-quadruplex; i-motif; triplex; non-canonical DNA; CATALYZED DIRECT ARYLATION; B-Z TRANSITION; SUBSTITUTED PYRIMIDINE NUCLEOSIDES; I-MOTIF STRUCTURES; C-H ARYLATION; Z-DNA; PURINE NUCLEOSIDES; G-QUADRUPLEX; MOLECULAR-STRUCTURE; HUMAN TELOMERE;

D O I：

10.3390/ijms22179552

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chemically modified nucleobases are thought to be important for therapeutic purposes as well as diagnosing genetic diseases and have been widely involved in research fields such as molecular biology and biochemical studies. Many artificially modified nucleobases, such as methyl, halogen, and aryl modifications of purines at the C8 position and pyrimidines at the C5 position, are widely studied for their biological functions. DNA containing these modified nucleobases can form non-canonical helical structures such as Z-DNA, G-quadruplex, i-motif, and triplex. This review summarizes the synthesis of chemically modified nucleotides: (i) methylation, bromination, and arylation of purine at the C8 position and (ii) methylation, bromination, and arylation of pyrimidine at the C5 position. Additionally, we introduce the non-canonical structures of nucleic acids containing these modifications.

引用

页数：23

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