Saxifraganoids A and B, two novel cucurbitane triterpenoid glycosides from Saxifraga umbellulata var. pectinata

被引：8

作者：

Jiang, Wei ^{[1
,2
]}

Fei, Yao ^{[3
]}

Du, Xiao-Lang ^{[1
,2
]}

Mu, Ze-Jing ^{[1
,2
]}

Li, Bo ^{[1
,2
]}

Zhang, Shou-Wen ^{[1
,2
]}

Zhong, Guo-Yue ^{[1
,2
]}

机构：

[1] Jiangxi Univ Tradit Chinese Med, Res Ctr Tradit Chinese Med Resources & Ethn Minor, Nanchang 330004, Jiangxi, Peoples R China

[2] Jiangxi Synergist Innovat Ctr Modern Technol & In, Nanchang 330004, Jiangxi, Peoples R China

[3] Chongqing Med Univ, Dept Tradit Chinese Med, Chongqing 400016, Peoples R China

来源：

TETRAHEDRON LETTERS | 2017年 / 58卷 / 36期

基金：

中国国家自然科学基金;

关键词：

Cucurbitane triterpenoid; Saxifraga umbellulata; Saxifraganoid; Liver injury; CHEMICAL-CONSTITUENTS; TANGUTICA;

D O I：

10.1016/j.tetlet.2017.07.093

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two novel cucurbitane triterpenoid glycosides, named saxifraganoids A (1) and B (2), were isolated from Saxifraga umbellulata var. pectinata. Their structures including absolute configurations were elucidated based on the analysis of spectroscopic data (1D, 2D NMR and HRMS), and single-crystal X-ray diffraction. Compound 1 represents the first example of cucurbitane triterpenoid with a Delta(17(20)), and compound 2 contained an unusual N-acetylglucosamine at C-16. The protective effects against liver injury induced by carbon tetrachloride (CCl4) in the human embryonic-liver L-02 cells of these two compounds were evaluated. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：3541 / 3544

页数：4

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