A slow-go prognosis for older patients with newly diagnosed AML

被引:2
作者
Schiller, Gary [1 ]
机构
[1] UCLA Hlth Sci, Los Angeles, CA 90095 USA
关键词
ACUTE MYELOID-LEUKEMIA;
D O I
10.1182/blood.2021012456
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
To determine which older patients may derive benefit from the prolonged pancytopenia and hospitalization associated with cytarabine-based induction chemotherapy, Itzykson et al, in this issue of Blood, report on a convenient clinical prognostic tool. The instrument, based on cytogenetic and molecular profiling, identifies which group of older and fit patients with newly diagnosed acute myeloid leukemia (AML) may derive survival benefit from intensive induction and consolidation chemotherapy.(1)
引用
收藏
页码:501 / 502
页数:2
相关论文
共 9 条
[1]   Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet [J].
Doehner, Hartmut ;
Estey, Elihu H. ;
Amadori, Sergio ;
Appelbaum, Frederick R. ;
Buechner, Thomas ;
Burnett, Alan K. ;
Dombret, Herve ;
Fenaux, Pierre ;
Grimwade, David ;
Larson, Richard A. ;
Lo-Coco, Francesco ;
Naoe, Tomoki ;
Niederwieser, Dietger ;
Ossenkoppele, Gert J. ;
Sanz, Miguel A. ;
Sierra, Jorge ;
Tallman, Martin S. ;
Loewenberg, Bob ;
Bloomfield, Clara D. .
BLOOD, 2010, 115 (03) :453-474
[2]   Validation and refinement of the revised 2017 European LeukemiaNet genetic risk stratification of acute myeloid leukemia [J].
Herold, Tobias ;
Rothenberg-Thurley, Maja ;
Grunwald, Victoria V. ;
Janke, Hanna ;
Goerlich, Dennis ;
Sauerland, Maria C. ;
Konstandin, Nikola P. ;
Dufour, Annika ;
Schneider, Stephanie ;
Neusser, Michaela ;
Ksienzyk, Bianka ;
Greif, Philipp A. ;
Subklewe, Marion ;
Faldum, Andreas ;
Bohlander, Stefan K. ;
Braess, Jan ;
Wormann, Bernhard ;
Krug, Utz ;
Berdel, Wolfgang E. ;
Hiddemann, Wolfgang ;
Spiekermann, Karsten ;
Metzeler, Klaus H. .
LEUKEMIA, 2020, 34 (12) :3161-3172
[3]   Genetic identification of patients with AML older than 60 years achieving long-term survival with intensive chemotherapy [J].
Itzykson, Raphael ;
Fournier, Elise ;
Berthon, Celine ;
Rollig, Christoph ;
Braun, Thorsten ;
Marceau-Renaut, Alice ;
Pautas, Cecile ;
Nibourel, Olivier ;
Lemasle, Emilie ;
Micol, Jean-Baptiste ;
Ades, Lionel ;
Lebon, Delphine ;
Malfuson, Jean-Valere ;
Gastaud, Lauris ;
Goursaud, Laure ;
Raffoux, Emmanuel ;
Wattebled, Kevin-James ;
Rousselot, Philippe ;
Thomas, Xavier ;
Chantepie, Sylvain ;
Cluzeau, Thomas ;
Serve, Hubert ;
Boissel, Nicolas ;
Terre, Christine ;
Celli-Lebras, Karine ;
Preudhomme, Claude ;
Thiede, Christian ;
Dombret, Herve ;
Gardin, Claude ;
Duployez, Nicolas .
BLOOD, 2021, 138 (07) :507-519
[4]   Gemtuzumab ozogamicin for de novo acute myeloid leukemia: final efficacy and safety updates from the open-label, phase III ALFA-0701 trial [J].
Lambert, Juliette ;
Pautas, Cecile ;
Terre, Christine ;
Raffoux, Emmanuel ;
Turlure, Pascal ;
Caillot, Denis ;
Legrand, Ollivier ;
Thomas, Xavier ;
Gardin, Claude ;
Gogat-Marchant, Karin ;
Rubin, Stephen D. ;
Benner, Rebecca J. ;
Bousset, Pierre ;
Preudhomme, Claude ;
Chevret, Sylvie ;
Dombret, Herve ;
Castaigne, Sylvie .
HAEMATOLOGICA, 2019, 104 (01) :113-119
[5]   CPX-351 (cytarabine and daunorubicin) Liposome for Injection Versus Conventional Cytarabine Plus Daunorubicin in Older Patients With Newly Diagnosed Secondary Acute Myeloid Leukemia [J].
Lancet, Jeffrey E. ;
Uy, Geoffrey L. ;
Cortes, Jorge E. ;
Newell, Laura F. ;
Lin, Tara L. ;
Ritchie, Ellen K. ;
Stuart, Robert K. ;
Strickland, Stephen A. ;
Hogge, Donna ;
Solomon, Scott R. ;
Stone, Richard M. ;
Bixby, Dale L. ;
Kolitz, Jonathan E. ;
Schiller, Gary J. ;
Wieduwilt, Matthew J. ;
Ryan, Daniel H. ;
Hoering, Antje ;
Banerjee, Kamalika ;
Chiarella, Michael ;
Louie, Arthur C. ;
Medeiros, Bruno C. .
JOURNAL OF CLINICAL ONCOLOGY, 2018, 36 (26) :2684-+
[6]   Allogeneic Hematopoietic Stem Cell Transplantation for Older Patients With Acute Myeloid Leukemia [J].
Levin-Epstein, Rebecca ;
Oliai, Caspian ;
Schiller, Gary .
CURRENT TREATMENT OPTIONS IN ONCOLOGY, 2018, 19 (12)
[7]   Ivosidenib induces deep durable remissions in patients with newly diagnosed IDH1-mutant acute myeloid leukemia [J].
Roboz, Gail J. ;
DiNardo, Courtney D. ;
Stein, Eytan M. ;
de Botton, Stephane ;
Mims, Alice S. ;
Prince, Gabrielle T. ;
Altman, Jessica K. ;
Arellano, Martha L. ;
Donnellan, Will ;
Erba, Harry P. ;
Mannis, Gabriel N. ;
Pollyea, Daniel A. ;
Stein, Anthony S. ;
Uy, Geoffrey L. ;
Watts, Justin M. ;
Fathi, Amir T. ;
Kantarjian, Hagop M. ;
Tallman, Martin S. ;
Choe, Sung ;
Dai, David ;
Fan, Bin ;
Wang, Hongfang ;
Zhang, Vickie ;
Yen, Katharine E. ;
Kapsalis, Stephanie M. ;
Hickman, Denice ;
Liu, Hua ;
Agresta, Samuel, V ;
Wu, Bin ;
Attar, Eyal C. ;
Stone, Richard M. .
BLOOD, 2020, 135 (07) :463-471
[8]   Epidemiology of acute myeloid leukemia: Recent progress and enduring challenges [J].
Shallis, Rory M. ;
Wang, Rong ;
Davidoff, Amy ;
Ma, Xiaomei ;
Zeidan, Amer M. .
BLOOD REVIEWS, 2019, 36 :70-87
[9]   Acute myeloid leukemia in the elderly: therapeutic options and choice [J].
Webster, Jonathan A. ;
Pratz, Keith W. .
LEUKEMIA & LYMPHOMA, 2018, 59 (02) :274-287