Precision of measurement of tissue optical properties with optical coherence tomography

被引：108
作者：
Kholodnykh, AI
Petrova, IY
Larin, KV
Motamedi, M
Esenaliev, RO
机构：
[1] Univ Texas, Med Branch, Galveston, TX 77555 USA
[2] VI Vernadskii Inst Geochem & Analyt Chem, Dept Anesthesiol, Moscow 117975, Russia
[3] VI Vernadskii Inst Geochem & Analyt Chem, Dept Ophthalmol & Visual Sci, Moscow 117975, Russia
[4] VI Vernadskii Inst Geochem & Analyt Chem, Dept Physiol & Biophys, Moscow 117975, Russia
[5] VI Vernadskii Inst Geochem & Analyt Chem, Ctr Biomed Engn, Moscow 117975, Russia
来源：
APPLIED OPTICS | 2003年 / 42卷 / 16期
关键词：
D O I：
10.1364/AO.42.003027
中图分类号：
O43 [光学];
学科分类号：
070207 ; 0803 ;
摘要：
Accurate and noninvasive measurement of tissue optical properties can be used for biomedical diagnostics and monitoring of tissue analytes. Noninvasive measurement of tissue optical properties (total attenuation and scattering coefficients, optical thickness, etc.) can be performed with the optical coherence tomography (OCT) technique. However, speckle noise substantially deteriorates the accuracy of the measurements with this technique. We studied suppression of speckle noise for accurate measurement of backscattering signal and scattering coefficient with the OCT technique. Our results demonstrate that the precision of measurement of backscattering signals with the OCT technique can be 0.2% for homogeneously scattering media and 0.7% for skin, if spatial averaging of speckle noise is applied. This averaging allows us to achieve the precision of tissue scattering coefficient measurements of approximately +/-0.8%. This precision can be further improved by a factor of 2-3, upon optimization of OCT operating parameters. (C) 2003 Optical Society of America.
引用
收藏
页码：3027 / 3037
页数：11
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