共 50 条
The Role of Genetic Variants in the Susceptibility of Noise-Induced Hearing Loss
被引:14
|作者:
Chen, Xue-min
[1
,2
,3
,4
,5
]
Xue, Xin-miao
[1
,2
,3
,4
,5
]
Yu, Ning
[2
,3
,4
,5
]
Guo, Wei-wei
[2
,3
,4
,5
]
Yuan, Shuo-long
[2
,3
,4
,5
]
Jiang, Qing-qing
[2
,3
,4
,5
]
Yang, Shi-ming
[2
,3
,4
,5
]
机构:
[1] Med Sch Chinese PLA, Beijing, Peoples R China
[2] Chinese Peoples Liberat Army Gen Hosp, Sr Dept Otolaryngol Head & Neck Surg, Beijing, Peoples R China
[3] Natl Clin Res Ctr Otolaryngol Dis, Beijing, Peoples R China
[4] Minist Educ, State Key Lab Hearing Sci, Beijing, Peoples R China
[5] Beijing Key Lab Hearing Impairment Prevent & Treat, Beijing, Peoples R China
基金:
中国国家自然科学基金;
关键词:
genes;
noised-induced hearing loss;
noise prevention;
susceptibility;
genetic variants;
MITOCHONDRIAL CELL-DEATH;
HAIR-CELL;
INCREASES SUSCEPTIBILITY;
OXIDATIVE STRESS;
LNCRNA HOTAIR;
INNER-EAR;
TIP-LINK;
CAT GENE;
ASSOCIATION;
POLYMORPHISMS;
D O I:
10.3389/fncel.2022.946206
中图分类号:
Q189 [神经科学];
学科分类号:
071006 ;
摘要:
Noised-induced hearing loss (NIHL) is an acquired, progressive neurological damage caused by exposure to intense noise in various environments including industrial, military and entertaining settings. The prevalence of NIHL is much higher than other occupational injuries in industrialized countries. Recent studies have revealed that genetic factors, together with environmental conditions, also contribute to NIHL. A group of genes which are linked to the susceptibility of NIHL had been uncovered, involving the progression of oxidative stress, potassium ion cycling, cilia structure, heat shock protein 70 (HSP70), DNA damage repair, apoptosis, and some other genes. In this review, we briefly summarized the studies primary in population and some animal researches concerning the susceptible genes of NIHL, intending to give insights into the further exploration of NIHL prevention and individual treatment.
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页数:17
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