Symptom and structure modifying properties of chondroitin sulfate in Osteoarthritis

被引:14
作者
Reginster, Jean-Yves [1 ]
Heraud, Florence
Zegels, Brigitte
Bruyere, Olivier
机构
[1] Univ Liege, Dept Publ Hlth Epidemiol & Hlth Econ, Liege, Belgium
[2] Univ Liege, Dept Publ Hlth Econ, Liege, Belgium
[3] Labs Genevrier, F-06901 Sophia Antipolis, France
关键词
chondroitin sulfate; sulfation patterns; cartilage; glycosaminoglycans; osteoarthritis; SYSADOAs;
D O I
10.2174/138955707782110088
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Chondroitin sulfate (CS) is a complex carbohydrate polymer with variable sulfation which impacts function. CS exhibits a wide range of biological activities. Many experimental and clinical data are available, affirming that CS represents an effective and safe symptomatic treatment of osteoarthritis (OA) with delayed and sustained effects.
引用
收藏
页码:1051 / 1061
页数:11
相关论文
共 80 条
[1]   INFLUENCE FUNCTIONALS - GENERAL METHODOLOGY FOR SUBSYSTEM CALCULATIONS [J].
ALLINGER, K ;
RATNER, MA .
PHYSICAL REVIEW A, 1989, 39 (02) :864-880
[2]   Glycosaminoglycan conformation: do aqueous molecular dynamics simulations agree with x-ray fiber diffraction? [J].
Almond, A ;
Sheehan, JK .
GLYCOBIOLOGY, 2000, 10 (03) :329-338
[3]   THE POSSIBLE ROLE OF NEUTROPHIL PROTEINASES IN DAMAGE TO ARTICULAR-CARTILAGE [J].
BARRETT, AJ .
AGENTS AND ACTIONS, 1994, 43 (3-4) :194-201
[4]  
BASSLEER C, 1992, INT J TISSUE REACT, V14, P231
[5]   A coarse-grained molecular model for glycosaminoglycans: Application to chondroitin, chondroitin sulfate, and hyaluronic acid [J].
Bathe, M ;
Rutledge, GC ;
Grodzinsky, AJ ;
Tidor, B .
BIOPHYSICAL JOURNAL, 2005, 88 (06) :3870-3887
[6]   Osmotic pressure of aqueous chondroitin sulfate solution: A molecular modeling investigation [J].
Bathe, M ;
Rutledge, GC ;
Grodzinsky, AJ ;
Tidor, B .
BIOPHYSICAL JOURNAL, 2005, 89 (04) :2357-2371
[7]   Sulfation of chondroitin sulfate in human articular cartilage - The effect of age, topographical position, and zone of cartilage on tissue composition [J].
Bayliss, MT ;
Osborne, D ;
Woodhouse, S ;
Davidson, C .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (22) :15892-15900
[8]   EXTRACELLULAR MAMMALIAN POLYSACCHARIDES - GLYCOSAMINOGLYCANS AND PROTEOGLYCANS [J].
BEATY, NB ;
MELLO, RJ .
JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1987, 418 :187-222
[9]   A MODIFIED URONIC ACID CARBAZOLE REACTION [J].
BITTER, T ;
MUIR, HM .
ANALYTICAL BIOCHEMISTRY, 1962, 4 (04) :330-&
[10]   Efficacy and tolerability of chondroitin sulfate 1200 mg/day vs chondroitin sulfate 3 x 400 mg/day vs placebo [J].
Bourgeois, P ;
Chales, G ;
Dehais, J ;
Delcambre, B ;
Kuntz, JL ;
Rozenberg, S .
OSTEOARTHRITIS AND CARTILAGE, 1998, 6 :25-30