Expression of c-kit protooncogene in human hepatocellular carcinoma

被引：29
|
作者：
Chung, CY
Yeh, KT
Hsu, NC
Chang, JHM
Lin, JT
Horng, HC
Chang, CS
机构：
[1] Changhua Christian Hosp, Dept Internal Med, Div Hematol Oncol, Changhua 500, Taiwan
[2] Changhua Christian Hosp, Dept Med Educ & Res, Changhua, Taiwan
[3] Changhua Christian Hosp, Dept Pathol, Changhua, Taiwan
来源：
CANCER LETTERS | 2005年 / 217卷 / 02期
关键词：
c-kit; human hepatocellular carcinoma; receptor tyrosine kinase;
D O I：
10.1016/j.canlet.2004.06.045
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The expression of the c-kit protooncogene in human hepatocellular carcinoma (HCC) was investigated. Immunohistochemical staining (IHC) and RT-PCR were employed to examine the protein and mRNA expression of c-kit protooncogene, respectively. IHC results demonstrated that 22 of 86 (25.6%) HCC tissue sections expressed c-kit protein. The c-kit mRNA transcript was further confirmed in all 22 IHC c-kit positive HCC tissue samples by RT-PCR. Moreover, the relationship between c-kit expression in HCC and prognosis of patients was statistically analyzed and a correlation was established. The group of patients whose HCC specimens showed positive c-kit staining exhibited better survival as compared to those patients with negative c-kit expression (p=0.021). These results suggest that c-kit expression may be a good prognostic indicator for HCC. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：231 / 236
页数：6
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