Ruxolitinib is more effective than other JAK inhibitors to treat VEXAS syndrome: a retrospective multicenter study

被引：148

作者：

Heiblig, Mael ^{[1
]}

Ferrada, Marcela A. ^{[2
]}

Koster, Matthew T. ^{[3
]}

Barba, Thomas ^{[4
]}

Gerfaud-Valentin, Mathieu ^{[5
]}

Mekinian, Arsene ^{[6
]}

Coelho, Henrique ^{[7
]}

Fossard, Gaelle ^{[1
]}

Barraco, Fiorenza ^{[1
]}

Galicier, Lionel ^{[8
]}

Bienvenu, Boris

Hirsch, Pierre ^{[9
]}

Vial, Guillaume ^{[10
]}

Boutin, Anne Blandine ^{[11
]}

Galland, Joris ^{[12
]}

Le Guenno, Guillaume ^{[13
]}

Bigot, Adrien ^{[14
]}

Warrington, Kenneth J. ^{[3
]}

Kermani, Tanaz A. ^{[15
]}

Grayson, Peter C. ^{[2
]}

Patel, Bhavisha A. ^{[16
]}

Beck, David B. ^{[17
,18
]}

Jamilloux, Yvan ^{[5
]}

Fenaux, Pierre ^{[19
,20
]}

Sujobert, Pierre ^{[21
]}

机构：

[1] Hosp Civils Lyon, Serv Hematol Clin, Hop Lyon Sud, Pierre B enite, France

[2] NIA, Musculoskeletal & Skin Dis, NIH, Bethesda, MD 20892 USA

[3] Mayo Clin, Div Rheumatol, Rochester, MN USA

[4] Hosp Civils Lyon, Dept Internal Med, Hop Edouard Herriot, Lyon, France

[5] Hosp Civils Lyon, Croix Rousse Univ Hosp, Lyon Imunopathol Federat LIFE, Internal Med, Lyon, France

[6] Hop St Antoine, Assistance Publ Hop Paris, Dept Internal Med, Paris, France

[7] Ctr Hosp Vila Nova Gaia, Dept Hematol, Porto, Portugal

[8] Hop St Joseph, Dept Internal Med, Marseille, France

[9] Sorbonne Univ, Assistance Publ Hop Paris, Serv Hematol Biol, Hop St Antoine, Paris, France

[10] Ctr Hosp Univ Bordeaux, Dept Internal Med & Clin Immunol, Bordeaux, France

[11] Ctr Hosp Alpes Leman, Dept Hematol, Contamine sur Arve, France

[12] Ctr Hosp Bourg Bresse, Med, Hop Fleyriat, Bourg en Bresse, France

[13] Ctr Hosp Univ Estaing, Serv Med Interne, Clermont Ferrand, France

[14] CHRU Tours, Tours, France

[15] Univ Calif Los Angeles, Los Angeles, CA USA

[16] Natl Heart Lung & Blood Inst, Hematol Branch, NIH, Bethesda, MD USA

[17] Natl Human Genome Res Inst, Natl Inst Hlth, Bethesda, MD USA

[18] NYU, New York, NY USA

[19] Hop St Louis, Assistance Publ Hop Paris, Paris, France

[20] Univ Paris, Paris, France

[21] Hosp Civils Lyon, Lab Hematol, Hop Lyon Sud, Pierre Benite, France

来源：

BLOOD | 2022年 / 140卷 / 08期

关键词：

RHEUMATOID-ARTHRITIS;

D O I：

10.1182/blood.2022016642

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：927 / 931

页数：5

共 12 条

[1] The Risk of Infections Associated With JAK Inhibitors in Rheumatoid Arthritis A Systematic Review and Network Meta-analysis [J].

Alves, Carlos ;

Penedones, Ana ;

Mendes, Diogo ;

Marques, Francisco Batel .

JCR-JOURNAL OF CLINICAL RHEUMATOLOGY, 2022, 28 (02) :E407-E414

[2] Somatic Mutations in UBA1 and Severe Adult-Onset Autoinflammatory Disease [J].

Beck, David B. ;

Ferrada, Marcela A. ;

Sikora, Keith A. ;

Ombrello, Amanda K. ;

Collins, Jason C. ;

Pei, Wuhong ;

Balanda, Nicholas ;

Ross, Daron L. ;

Ospina Cardona, Daniela ;

Wu, Zhijie ;

Patel, Bhavisha ;

Manthiram, Kalpana ;

Groarke, Emma M. ;

Gutierrez-Rodrigues, Fernanda ;

Hoffmann, Patrycja ;

Rosenzweig, Sofia ;

Nakabo, Shuichiro ;

Dillon, Laura W. ;

Hourigan, Christopher S. ;

Tsai, Wanxia L. ;

Gupta, Sarthak ;

Carmona-Rivera, Carmelo ;

Asmar, Anthony J. ;

Xu, Lisha ;

Oda, Hirotsugu ;

Goodspeed, Wendy ;

Barron, Karyl S. ;

Nehrebecky, Michele ;

Jones, Anne ;

Laird, Ryan S. ;

Deuitch, Natalie ;

Rowczenio, Dorota ;

Rominger, Emily ;

Wells, Kristina V. ;

Lee, Chyi-Chia R. ;

Wang, Weixin ;

Trick, Megan ;

Mullikin, James ;

Wigerblad, Gustaf ;

Brooks, Stephen ;

Dell'Orso, Stefania ;

Deng, Zuoming ;

Chae, Jae J. ;

Dulau-Florea, Alina ;

Malicdan, May C. V. ;

Novacic, Danica ;

Colbert, Robert A. ;

Kaplan, Mariana J. ;

Gadina, Massimo ;

Savic, Sinisa .

NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (27) :2628-2638

[3] Therapeutic options in VEXAS syndrome: insights from a retrospective series [J].

Bourbon, Estelle ;

Heiblig, Mael ;

Valentin, Mathieu Gerfaud ;

Barba, Thomas ;

Durel, Cecile-Audrey ;

Lega, Jean Christophe ;

Barraco, Fiorenza ;

Seve, Pascal ;

Jamilloux, Yvan ;

Sujobert, Pierre .

BLOOD, 2021, 137 (26) :3682-3684

[4] Autoimmune pathways in mice and humans are blocked by pharmacological stabilization of the TYK2 pseudokinase domain [J].

Burke, James R. ;

Cheng, Lihong ;

Gillooly, Kathleen M. ;

Strnad, Joann ;

Zupa-Fernandez, Adriana ;

Catlett, Ian M. ;

Zhang, Yifan ;

Heimrich, Elizabeth M. ;

McIntyre, Kim W. ;

Cunningham, Mark D. ;

Carman, Julie A. ;

Zhou, Xiadi ;

Banas, Dana ;

Chaudhry, Charu ;

Li, Sha ;

D'Arienzo, Celia ;

Chimalakonda, Anjaneya ;

Yang, XiaoXia ;

Xie, Jenny H. ;

Pang, Jian ;

Zhao, Qihong ;

Rose, Shawn M. ;

Huang, Jinwen ;

Moslin, Ryan M. ;

Wrobleski, Stephen T. ;

Weinstein, David S. ;

Salter-Cid, Luisa M. .

SCIENCE TRANSLATIONAL MEDICINE, 2019, 11 (502)

[5] Azacitidine for patients with Vacuoles, E1 Enzyme, X-linked, Autoinflammatory, Somatic syndrome (VEXAS) and myelodysplastic syndrome: data from the French VEXAS registry [J].

Comont, Thibault ;

Heiblig, Mael ;

Riviere, Etienne ;

Terriou, Louis ;

Rossignol, Julien ;

Bouscary, Didier ;

Rieu, Virginie ;

Le Guenno, Guillaume ;

Mathian, Alexis ;

Aouba, Achille ;

Vinit, Julien ;

Dion, Jeremie ;

Kosmider, Olivier ;

Terrier, Benjamin ;

Georgin-Lavialle, Sophie ;

Fenaux, Pierre ;

Mekinian, Arsene .

BRITISH JOURNAL OF HAEMATOLOGY, 2022, 196 (04) :969-974

[6] Translating JAKs to Jakinibs [J].

Gadina, Massimo ;

Chisolm, Danielle A. ;

Philips, Rachael L. ;

McInness, Lain B. ;

Changelian, Paul S. ;

O'Shea, John J. .

JOURNAL OF IMMUNOLOGY, 2020, 204 (08) :2011-2020

[7] Further characterization of clinical and laboratory features in VEXAS syndrome: large-scale analysis of a multicentre case series of 116 French patients [J].

Georgin-Lavialle, S. ;

Terrier, B. ;

Guedon, A. F. ;

Heiblig, M. ;

Comont, T. ;

Lazaro, E. ;

Lacombe, V ;

Terriou, L. ;

Ardois, S. ;

Bouaziz, J-D ;

Mathian, A. ;

Le Guenno, G. ;

Aouba, A. ;

Outh, R. ;

Meyer, A. ;

Roux-Sauvat, M. ;

Ebbo, M. ;

Zhao, L. P. ;

Bigot, A. ;

Jamilloux, Y. ;

Guillotin, V ;

Flamarion, E. ;

Henneton, P. ;

Vial, G. ;

Jachiet, V ;

Rossignol, J. ;

Vinzio, S. ;

Weitten, T. ;

Vinit, J. ;

Deligny, C. ;

Humbert, S. ;

Samson, M. ;

Magy-Bertrand, N. ;

Moulinet, T. ;

Bourguiba, R. ;

Hanslik, T. ;

Bachmeyer, C. ;

Sebert, M. ;

Kostine, M. ;

Bienvenu, B. ;

Biscay, P. ;

Liozon, E. ;

Sailler, L. ;

Chasset, F. ;

Audemard-Verger, A. ;

Duroyon, E. ;

Sarrabay, G. ;

Borlot, F. ;

Dieval, C. ;

Cluzeau, T. .

BRITISH JOURNAL OF DERMATOLOGY, 2022, 186 (03) :564-574

[8] Benign and malignant hematologic manifestations in patients with VEXAS syndrome due to somatic mutations in UBA1 [J].

Obiorah, Ifeyinwa Emmanuela ;

Patel, Bhavisha A. ;

Groarke, Emma M. ;

Wang, Weixin ;

Trick, Megan ;

Ombrello, Amanda K. ;

Ferrada, Marcela A. ;

Wu, Zhijie ;

Gutierrez-Rodrigues, Fernanda ;

Lotter, Jennifer ;

Wilson, Lorena ;

Hoffmann, Patrycja ;

Cardona, Daniela Ospina ;

Patel, Nisha ;

Dulau-Florea, Alina ;

Kastner, Daniel L. ;

Grayson, Peter C. ;

Beck, David B. ;

Young, Neal S. ;

Calvo, Katherine R. .

BLOOD ADVANCES, 2021, 5 (16) :3203-3215

[9] Risk of admission to hospital for serious infection after initiating tofacitinib versus biologic DMARDs in patients with rheumatoid arthritis: a multidatabase cohort study [J].

Pawar, Ajinkya ;

Desai, Rishi J. ;

Gautam, Nileesa ;

Kim, Seoyoung C. .

LANCET RHEUMATOLOGY, 2020, 2 (02) :E84-E98

[10] Thromboembolism with Janus Kinase (JAK) Inhibitors for Rheumatoid Arthritis: How Real is the Risk? [J].

Scott, Ian C. ;

Hider, Samantha L. ;

Scott, David L. .

DRUG SAFETY, 2018, 41 (07) :645-653

← 1 2 →