Absence of angiogenic genes modification in Italian ALS patients

被引：42

作者：

Del Bo, Roberto ^{[1
]}

Scarlato, Marina ^{[1
]}

Ghezzi, Serena ^{[1
]}

Martinelli-Boneschi, Filippo

Corti, Stefania ^{[1
,2
]}

Locatelli, Federica ^{[1
]}

Santoro, Domenico ^{[1
]}

Prelle, Alessandro ^{[1
]}

Briani, Chiara ^{[3
]}

Nardini, Martina ^{[4
]}

Siciliano, Gabriele ^{[4
]}

Mancuso, Michelangelo ^{[4
]}

Murri, Luigi ^{[4
]}

Bresolin, Nereo ^{[1
]}

Comi, Giacomo Pietro ^{[1
]}

机构：

[1] Univ Milan, IRCCS Fdn, Osped Maggiore Policlin Mangiagalli & Regina Elen, Dino Ferrari Ctr,Dept Neurol Sci, Milan, Italy

[2] Sci Inst & Univ, Osped San Raffaele, Dept Neurol, Milan, Italy

[3] Univ Padua, Dept Neurosci, Padua, Italy

[4] Univ Pisa, Dept Neurosci, Neurol Inst, Pisa, Italy

来源：

NEUROBIOLOGY OF AGING | 2008年 / 29卷 / 02期

关键词：

amyotrophic lateral sclerosis; vascular endothelial growth factor; angiogenin; genetic risk factor; meta-analysis;

D O I：

10.1016/j.neurobiolaging.2006.10.008

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

To investigate the role of vascular endothelial growth factor (VEGF) and angiogenin (ANG) as genetic determinants in the susceptibility to sporadic ALS in Italian patients. VEGF genotype and haplotype analysis revealed no association between any variants and the risk of ALS. Regarding ANG gene, no mutation was detected and the rs11701 polymorphism, previously described as associated with ALS, was not differently distributed between patients and controls. Overall, our data argue against the hypothesis of both genes as risk factors for motoneuron neurodegeneration, at least in an Italian population. (C) 2006 Elsevier Inc. All rights reserved.

引用

页码：314 / 316

页数：3