THE CAT AND SOD ACTIVITIES IN PATIENTS WITH CHRONIC SUPPURATIVE OTITIS MEDIA

被引：3

作者：

Serban, Roxana ^{[1
]}

Badescu, Codruta ^{[2
]}

Filip, Alexandru ^{[3
]}

Cobzeanu, Mihail Dan ^{[4
]}

Badescu, Magda ^{[1
]}

Butnaru, Corina ^{[4
]}

Huzum, Bogdan ^{[5
]}

Filip, Cristiana ^{[6
]}

机构：

[1] Univ Med & Pharm Grigore T Popa, Fac Med, Pathophysiol Dept, 16 Univ St, Iasi 700115, Romania

[2] Univ Med & Pharm Grigore T Popa, Fac Med, Dept Internal Med, 16 Univ St, Iasi 700115, Romania

[3] Univ Med & Pharm Grigore T Popa, Fac Med, Dept Orthopaed & Traumatol, 16 Univ St, Iasi 700115, Romania

[4] Univ Med & Pharm Grigore T Popa, Fac Med, Otorhinolaryngol Dept, 16 Univ St, Iasi 700115, Romania

[5] Univ Med & Pharm Grigore T Popa, Fac Med, 16 Univ St, Iasi 700115, Romania

[6] Univ Med & Pharm Grigore T Popa, Fac Med, Dept Biochem, 16 Univ St, Iasi 700115, Romania

来源：

FARMACIA | 2018年 / 66卷 / 06期

关键词：

cholesteatoma; oxidative stress; chronic otitis media; catalase; OXIDATIVE STRESS; SERUM; CATALASE; ANTIOXIDANTS; ENZYMES; BIOLOGY;

D O I：

10.31925/FARMACIA.2018.6.9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Oxidative stress plays an important role in multiple diseases by disturbing the oxidant-antioxidant balance. The aim of this study was to evaluate the antioxidative status in patients with chronic suppurative otitis media (CSOM). We conducted a prospective study that included 60 patients diagnosed with chronic suppurative otitis media with and without cholesteatoma. The catalase (CAT) and superoxide dismutase (SOD) activities were determined in erythrocytes respectively serum of the patients. We noticed that the antioxidant enzyme SOD activity in the patients with CSOM with and without cholesteatoma had statistically significant lower values compared to the healthy subjects (p < 0.05). For the same groups the CAT activity was statistically significant increased (p < 0.05) as compared to the healthy group. As a conclusion, oxidative stress seems to be involved in the pathogenesis of CSOM with and without cholesteatoma, leading to chronic infections and tissue injury.

引用

页码：984 / 988

页数：5

共 22 条

[1]

Aktan B, 2003, ANN CLIN LAB SCI, V33, P232

[2]

Al-Abrash ASA, 2000, SAUDI MED J, V21, P826

[3]

Albu E, 2013, FARMACIA, V61, P1167

[4] NADPH oxidase [J].

Babior, BM .

CURRENT OPINION IN IMMUNOLOGY, 2004, 16 (01) :42-47

[5] Oxidative stress in chronic otitis media [J].

Baysal, Elif ;

Aksoy, Nurten ;

Kara, Ferit ;

Taysi, Seyithan ;

Taskin, Abdullah ;

Bilinc, Hasan ;

Cevik, Cengiz ;

Celenk, Fatih ;

Kanlikama, Muzaffer .

EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY, 2013, 270 (04) :1203-1208

[6] IDIOPATHIC SUDDEN HEARING LOSS: OXIDATIVE STATUS BEFORE AND AFTER CORTICOID TREATMENT [J].

Cavaleriu, Bogdan D. ;

Martu, Dan V. ;

Hritcu, Lucian ;

Manolachel, Oana R. ;

Radulescu, Luminita M. .

ARCHIVES OF BIOLOGICAL SCIENCES, 2015, 67 (04) :1297-1302

[7] Gene expression of antioxidative enzymes in the human heart - Increased expression of catalase in the end-stage failing heart [J].

Dieterich, S ;

Bieligk, U ;

Beulich, K ;

Hasenfuss, G ;

Prestle, J .

CIRCULATION, 2000, 101 (01) :33-39

[8]

Filip C, 2017, FARMACIA, V65, P596

[9] The Evaluation of Oxidative Stress in the Serum and Tissue Specimens of Patients With Chronic Otitis Media [J].

Garca, Mehmet Fatih ;

Turan, Mahfuz ;

Avsar, Baris ;

Kalkan, Ferhat ;

Demir, Halit ;

Kozan, Ahmet ;

Bozan, Nazim .

CLINICAL AND EXPERIMENTAL OTORHINOLARYNGOLOGY, 2015, 8 (02) :97-101

[10] Serum Myeloperoxidase Activity, Total Antioxidant Capacity and Nitric Oxide Levels in Patients with Chronic Otitis Media [J].

Garca, Mehmet Fatih ;

Aslan, Mehmet ;

Tuna, Bakir ;

Kozan, Ahmet ;

Cankaya, Hakan .

JOURNAL OF MEMBRANE BIOLOGY, 2013, 246 (07) :519-524

← 1 2 3 →