Low humidity stimulates epidermal DNA synthesis and amplifies the hyperproliferative response to barrier disruption: Implication for seasonal exacerbations of inflammatory dermatoses

被引:183
作者
Denda, M
Sato, J
Tsuchiya, T
Elias, PM
Feingold, KR
机构
[1] Shiseido Res Ctr, Skin Biol Res Lab, Kanazawa Ku, Yokohama, Kanagawa, Japan
[2] Vet Affairs Med Ctr, Dermatol Sect, San Francisco, CA 94121 USA
[3] Vet Affairs Med Ctr, Med Metab Sect, San Francisco, CA 94121 USA
[4] Univ Calif San Francisco, Dept Dermatol, San Francisco, CA 94143 USA
[5] Univ Calif San Francisco, Dept Med, San Francisco, CA USA
关键词
dry environment; humectant; mast cell occlusion;
D O I
10.1046/j.1523-1747.1998.00364.x
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Although seasonal changes in humidity are thought to exacerbate various skin diseases, whether these flares can be attributed to prolonged exposure to extremes in environmental humidities has not been studied systematically. We recently showed that prolonged exposure to high versus low humidities induced profound changes in epidermal structure and permeability barrier homeostasis, Therefore, we asked here whether comparable extremes in humidity could initiate not only homeostatic, but also potentially pathophysiologic alterations. We showed first that exposure to low humidity increases epidermal DNA synthesis in normal murine epidermis, Moreover, exposure to a low humidity for 48 h further amplifies the DNA synthetic response to barrier disruption, resulting in marked epidermal hyperplasia. Additionally, exposure to a dry environment for 48 h prior to barrier disruption results in dermal mast cell hypertrophy, degranulation, as well as histologic evidence of inflammation, To demonstrate the role of changes in external moisture on these phenomena, we applied either an occlusive, water-impermeable plastic membrane, Petrolatum, or a nonocclusive humectant, both to nonperturbated and to perturbed skin. All three forms of treatment prevented the epidermal hyperplasia and dermal mast cell hypertrophy and degranulation induced by exposure to low humidity, These studies indicate that (i) exposure to changes in environmental humidity alone induces increased keratinocyte proliferation and markers of inflammation, and (ii) that these changes are attributable to changes in stratum corneum moisture content. Finally, these studies provide evidence that changes in environmental humidity contribute to the seasonal exacerbations/amelioration of cutaneous disorders, such as atopic dermatitis and psoriasis, diseases which are characterized by a defective barrier, epidermal hyperplasia, and inflammation.
引用
收藏
页码:873 / 878
页数:6
相关论文
共 14 条
[1]  
CHERNOSKY ME, 1976, J SOC COSMET CHEM, V27, P365
[2]   The epidermal hyperplasia associated with repeated barrier disruption by acetone treatment or tape stripping cannot be attributed to increased water loss [J].
Denda, M ;
Wood, LC ;
Emami, S ;
Calhoun, C ;
Brown, BE ;
Elias, PM ;
Feingold, KR .
ARCHIVES OF DERMATOLOGICAL RESEARCH, 1996, 288 (5-6) :230-238
[3]  
DENDA M, 1998, IN PRESS J INVEST DE, V111
[4]  
ELIAS PM, 1992, SEMIN DERMATOL, V11, P176
[5]   EFFECT OF PLASTIC OCCLUSIVE DRESSINGS ON PSORIATIC EPIDERMIS [J].
FRY, L ;
ALMEYDA, J ;
MCMINN, RMH .
BRITISH JOURNAL OF DERMATOLOGY, 1970, 82 (05) :458-&
[6]  
GRICE KA, 1980, PHYSL PATHOPHYSIOLOG, P2147
[7]  
*NAT RES COUNC, 1996, GUID CAR US LAB AN
[8]   PREDICTION OF SUSCEPTIBILITY TO AN IRRITANT RESPONSE BY TRANS-EPIDERMAL WATER-LOSS [J].
PINNAGODA, J ;
TUPKER, RA ;
COENRAADS, PJ ;
NATER, JP .
CONTACT DERMATITIS, 1989, 20 (05) :341-346
[9]   STRATUM-CORNEUM MOISTURIZATION AT THE MOLECULAR-LEVEL [J].
RAWLINGS, AV ;
SCOTT, IR ;
HARDING, CR ;
BOWSER, PA .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1994, 103 (05) :731-740
[10]   LOW HUMIDITY OCCUPATIONAL DERMATOSES [J].
RYCROFT, RJG ;
SMITH, WDL .
CONTACT DERMATITIS, 1980, 6 (07) :488-492