Surface engineering for lymphocyte programming

被引：20

作者：

Ben-Akiva, Elana ^{[1
,2
,3
,4
]}

Meyer, Randall A. ^{[1
,2
,3
]}

Wilson, David R. ^{[1
,2
,3
]}

Green, Jordan J. ^{[1
,2
,3
,4
,5
,6
,7
,8
,9
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Biomed Engn, Baltimore, MD 21231 USA

[2] Johns Hopkins Univ, Sch Med, Translat Tissue Engn Ctr, Baltimore, MD 21231 USA

[3] Johns Hopkins Univ, Sch Med, Inst Nanobiotechnol, Baltimore, MD 21231 USA

[4] Johns Hopkins Univ, Sch Med, Johns Hopkins Bloomberg Kimmel Inst Canc Immunoth, Baltimore, MD 21231 USA

[5] Johns Hopkins Univ, Dept Mat Sci & Engn, Sch Med, Baltimore, MD 21231 USA

[6] Johns Hopkins Univ, Dept Chem & Biomol Engn, Sch Med, Baltimore, MD 21231 USA

[7] Johns Hopkins Univ, Sch Med, Dept Ophthalmol, Baltimore, MD 21231 USA

[8] Johns Hopkins Univ, Sch Med, Dept Oncol, Baltimore, MD 21231 USA

[9] Johns Hopkins Univ, Sch Med, Dept Neurosurg, Baltimore, MD 21231 USA

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2017年 / 114卷

关键词：

Lymphocyte engineering; Nanoparticle; Microparticle; Artificial antigen presenting cell; ANTIGEN-PRESENTING CELLS; T-CELLS; IMMUNOLOGICAL-SYNAPSE; PARTICLE-SHAPE; EX-VIVO; B-CELLS; SYNTHETIC NANOPARTICLES; MECHANICAL-PROPERTIES; DENDRITIC CELLS; CUTTING EDGE;

D O I：

10.1016/j.addr.2017.05.005

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The once nascent field of immunoengineering has recently blossomed to include approaches to deliver and present biomolecules to program diverse populations of lymphocytes to fight disease. Building upon improved understanding of the molecular and physical mechanics of lymphocyte activation, varied strategies for engineering surfaces to activate and deactivate T-Cells, B-Cells and natural killer cells are in preclinical and clinical development. Surfaces have been engineered at the molecular level in terms of the presence of specific biological factors, their arrangement, on a surface, and their diffusivity to elicit specific lymphocyte fates. In addition, the physical and mechanical characteristics of the surface including shape, anisotropy, and rigidity of particles for lymphocyte activation have been fine-tuned. Utilizing these strategies, acellular systems have been engineered for the expansion of T-Cells and natural killer cells to clinically relevant levels for cancer therapies as well as engineered to program B-Cells to better combat infectious diseases. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：102 / 115

页数：14

共 143 条

[111] Absorbable microparticulate cation exchanger for immunotherapeutic delivery [J].