Endothelial nitric oxide synthase:: a determinant of TNFα production by human monocytes/macrophages

被引：28
|
作者：
Mühl, H [1 ]
Pfeilschifter, J [1 ]
机构：
[1] Univ Frankfurt Klinikum, Pharmazentrum Frankfurt, D-60590 Frankfurt, Germany
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2003年 / 310卷 / 03期
关键词：
endothelial nitric oxide synthase; inducible nitric oxide synthase; inflammation; monocytes; macrophages; tumor necrosis factor-alpha; N-6-monomethyl-L-arginine;
D O I：
10.1016/j.bbrc.2003.09.039
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Until recently endothelial nitric oxide synthase (eNOS) has been associated exclusively with physiological functions, particularly in the cardiovascular system. However, increasing evidence has been accumulated that supports the concept for a role of eNOS in pathophysiology. In particular, detection of eNOS protein and activity in human monocytes/macrophages suggest an immunomodulatory role of this enzyme. Here, we review data that promote the hypothesis that by enhancing TNFalpha production, eNOS activity should be regarded as a novel pro-inflammatory parameter in human monocytes/macrophages. (C) 2003 Elsevier Inc. All rights reserved.
引用
收藏
页码：677 / 680
页数：4
相关论文
共 50 条
  • [1] Nitric oxide production and expression of inducible and endothelial nitric oxide synthase by hamster macrophages
    Ramírez-Emiliano, J
    González-Hernández, A
    Arias-Negrete, S
    FREE RADICAL BIOLOGY AND MEDICINE, 2003, 35 : S88 - S88
  • [2] Vasoactive hormones induce nitric oxide synthase mRNA expression and nitric oxide production in human endothelial cells and monocytes
    Schena, M
    Mulatero, P
    Schiavone, D
    Mengozzi, G
    Tesio, L
    Chiandussi, L
    Veglio, F
    AMERICAN JOURNAL OF HYPERTENSION, 1999, 12 (04) : 388 - 397
  • [3] Constitutive endothelial nitric oxide synthase (ecNOS) gene expression in human monocytes
    Calo, L
    Davis, PA
    Milani, M
    Antonello, A
    Cantaro, S
    D'Angelo, A
    Fagiolo, U
    ANGIOLOGY, 1998, 49 (06) : 419 - 422
  • [4] Release of nitric oxide by human monocytes/macrophages
    Moncada, S
    BRITISH JOURNAL OF CANCER, 1996, 73 (08) : 1014 - 1014
  • [5] Reduced endothelial nitric oxide synthase expression and production in human atherosclerosis
    Oemar, BS
    Tschudi, MR
    Godoy, N
    Brovkovich, V
    Malinski, T
    Lüscher, TF
    CIRCULATION, 1998, 97 (25) : 2494 - 2498
  • [6] Neuropeptides induce nitric oxide synthase expression and nitric oxide production in human dermal endothelial cells
    Gyulai, R
    Kemény, L
    Dobozy, A
    Michel, G
    Suschek, C
    Kolb-Bachofen, V
    Ruzicka, T
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1998, 111 (02) : 345 - 345
  • [7] Effects of endurance training on expression endothelial nitric oxide synthase and nitric oxide production in human placenta
    Ramirez-Velez, Robinson
    CIRCULATION, 2012, 125 (19) : E916 - E916
  • [8] Nitric oxide production and inducible nitric oxide synthase expression by monocytes in systemic sclerosis
    Menkès, CJ
    Allanore, Y
    Borderie, D
    Hilliquin, P
    Hernvann, A
    Ekindjian, O
    Kahan, A
    BULLETIN DE L ACADEMIE NATIONALE DE MEDECINE, 2001, 185 (03): : 509 - 523
  • [9] An endogenous inhibitor of nitric oxide synthase regulates endothelial adhesiveness for monocytes
    Böger, RH
    Bode-Böger, SM
    Tsao, PS
    Lin, PS
    Chan, JR
    Cooke, JP
    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2000, 36 (07) : 2287 - 2295
  • [10] Deferiprone increases endothelial nitric oxide synthase phosphorylation and nitric oxide production
    Sriwantana, Thanaporn
    Vivithanaporn, Pornpun
    Paiboonsukwong, Kittiphong
    Rattanawonsakul, Krit
    Srihirun, Sirada
    Sibmooh, Nathawut
    CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2018, 96 (09) : 879 - 885
12345