From Pathology to Precision Medicine in Anaplastic Large Cell Lymphoma Expressing Anaplastic Lymphoma Kinase (ALK plus ALCL)

被引：8

作者：

Werner, Michael T. ^{[1
]}

Zhang, Qian ^{[1
]}

Wasik, Mariusz A. ^{[1
]}

机构：

[1] Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

来源：

CANCERS | 2017年 / 9卷 / 10期

关键词：

anaplastic lymphoma kinase; anaplastic large cell lymphoma; NPM-ALK; ALK plus ALCL; precision medicine; RECEPTOR TYROSINE KINASE; NON-HODGKINS-LYMPHOMA; STAT3; ACTIVATION; NPM; PROTEIN; GENE; TRANSLOCATIONS; CRIZOTINIB; CLASSIFICATION; TRANSFORMATION;

D O I：

10.3390/cancers9100138

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Anaplastic large cell lymphoma expressing anaplastic lymphoma kinase (ALK+ ALCL) is a distinct subtype of non-Hodgkin lymphoma. In this review, we discuss the historical findings that led to its classification as a unique disease, despite its varied clinical presentation and histology. We discuss the molecular mechanisms underlying ALK+ ALCL pathology and the questions that remain in the field. Finally, we visit how decades of ALK+ ALCL research has yielded more precise drugs that hold promise for the future.

引用

页数：8

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