From Pathology to Precision Medicine in Anaplastic Large Cell Lymphoma Expressing Anaplastic Lymphoma Kinase (ALK plus ALCL)

被引:8
作者
Werner, Michael T. [1 ]
Zhang, Qian [1 ]
Wasik, Mariusz A. [1 ]
机构
[1] Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA
关键词
anaplastic lymphoma kinase; anaplastic large cell lymphoma; NPM-ALK; ALK plus ALCL; precision medicine; RECEPTOR TYROSINE KINASE; NON-HODGKINS-LYMPHOMA; STAT3; ACTIVATION; NPM; PROTEIN; GENE; TRANSLOCATIONS; CRIZOTINIB; CLASSIFICATION; TRANSFORMATION;
D O I
10.3390/cancers9100138
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Anaplastic large cell lymphoma expressing anaplastic lymphoma kinase (ALK+ ALCL) is a distinct subtype of non-Hodgkin lymphoma. In this review, we discuss the historical findings that led to its classification as a unique disease, despite its varied clinical presentation and histology. We discuss the molecular mechanisms underlying ALK+ ALCL pathology and the questions that remain in the field. Finally, we visit how decades of ALK+ ALCL research has yielded more precise drugs that hold promise for the future.
引用
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页数:8
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