A cross-sectional analysis of the associations between adult height, BMI and serum concentrations of IGF-I and IGFBP-1-2 and-3 in the European Prospective Investigation into Cancer and Nutrition (EPIC)

被引：62

作者：

Crowe, Francesca L. ^{[1
]}

Key, Timothy J. ^{[1
]}

Allen, Naomi E. ^{[1
]}

Appleby, Paul N. ^{[1
]}

Overvad, Kim ^{[2
,3
]}

Gronbaek, Henning ^{[4
]}

Tjonneland, Anne ^{[5
]}

Halkjaer, Jytte ^{[6
]}

Dossus, Laure ^{[6
]}

Boeing, Heiner ^{[7
]}

Kroeger, Janine ^{[7
]}

Trichopoulou, Antonia ^{[8
]}

Zylis, Dimosthenis ^{[8
]}

Trichopoulos, Dimitrios ^{[9
,10
]}

Boutron-Ruault, Marie-Christine ^{[11
]}

de Lauzon-Guillain, Blandine ^{[11
]}

Clavel-Chapelon, Francoise ^{[11
]}

Palli, Domenico ^{[12
]}

Berrino, Franco ^{[13
]}

Panico, Salvatore ^{[14
]}

Tumino, Rosario

Sacerdote, Carlotta ^{[15
]}

Bueno-de-Mesquita, H. Bas ^{[16
,17
]}

van Gils, Carla H. ^{[18
]}

Peeters, Petra H. M. ^{[18
,19
]}

Gram, Inger T. ^{[20
]}

Rodriguez, Laudina ^{[21
]}

Jakszyn, Paula ^{[22
]}

Molina-Montes, Esther ^{[23
]}

Navarro, Carmen ^{[24
]}

Barricarte, Aurelio ^{[25
]}

Larranaga, Nerea ^{[26
]}

Khaw, Kay-Tee ^{[27
]}

Rodwell, Sheila ^{[28
,29
]}

Rinaldi, Sabina ^{[30
]}

Slimani, Nadia ^{[30
]}

Norat, Teresa ^{[19
]}

Gallo, Valentina ^{[19
]}

Riboli, Elio ^{[19
]}

Kaaks, Rudolf ^{[6
]}

机构：

[1] Univ Oxford, Canc Epidemiol Unit, Nuffield Dept Clin Med, Oxford OX3 7LF, England

[2] Aarhus Univ, Sch Publ Hlth, Dept Epidemiol, Aarhus, Denmark

[3] Aarhus Univ Hosp, Dept Cardiol, Aalborg Hosp, Aalborg, Denmark

[4] Aarhus Univ Hosp, Med Dept 5, DK-8000 Aarhus, Denmark

[5] Inst Canc Epidemiol, Danish Canc Soc, Copenhagen, Denmark

[6] German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany

[7] German Inst Human Nutr Potsdam Rehbrucke, Nuthetal, Germany

[8] Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, WHO Collaborating Ctr Food & Nutr Policies, GR-11527 Athens, Greece

[9] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[10] Acad Athens, Bur Epidemiol Res, Athens, Greece

[11] Ctr Res Epidemiol & Populat Hlth CESP, Villejuif, France

[12] ISPO Canc Res & Prevent Inst, Mol & Nutr Epidemiol Unit, Florence, Italy

[13] IRCCS Ist Nazl Tumori, Etiol Epidemiol & Prevent Unit, Milan, Italy

[14] Univ Naples Federico II, Dept Clin & Expt Med, Naples, Italy

[15] Epidemiol & Prevenz Oncol CPO Piemonte, Turin, Italy

[16] Natl Inst Publ Hlth & Environm RIVM, Bilthoven, Netherlands

[17] Univ Med Ctr Utrecht, Dept Gastroenterol & Hepatol, Utrecht, Netherlands

[18] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[19] Univ London Imperial Coll Sci Technol & Med, Fac Med, Dept Epidemiol & Publ Hlth, London, England

[20] Univ Tromso, Inst Community Med, Tromso, Norway

[21] Hlth & Hlth Care Serv Council, Publ Hlth & Participat Directorate, Asturias, Spain

[22] Catalan Inst Oncol ICO, Canc Epidemiol Res Programme, Unit Nutr Environm & Canc, Barcelona, Spain

[23] Andalusian Sch Publ Hlth, Granada, Spain

[24] Murcia Hlth Council, Dept Epidemiol, Murcia, Spain

[25] Publ Hlth Inst Navarra, Pamplona, Spain

[26] Basque Govt, Publ Hlth Dept Gipuzkoa, Madrid, Spain

[27] Univ Cambridge, Sch Clin Med, Inst Publ Hlth, Dept Publ Hlth & Primary Care, Cambridge, England

[28] Univ Cambridge, Dunn Human Nutr Unit, MRC, Cambridge, England

[29] Univ Cambridge, Dept Publ Hlth & Primary Care, MRC, Ctr Nutr Epidemiol Canc Prevent & Survival, Cambridge, England

[30] Int Agcy Res Canc IARC WHO, Lyon, France

来源：

ANNALS OF HUMAN BIOLOGY | 2011年 / 38卷 / 02期

关键词：

Body height; body mass index; insulin-like growth factor I; insulin-like growth factor binding proteins; obesity; GROWTH-FACTOR-I; BODY-MASS INDEX; FACTOR BINDING-PROTEIN-3 CONCENTRATIONS; BINDING-PROTEIN; FACTOR (IGF)-I; C-PEPTIDE; INSULIN; RISK; WOMEN; HORMONE;

D O I：

10.3109/03014460.2010.507221

中图分类号：

Q98 [人类学];

学科分类号：

030303 ;

摘要：

Background: Height and BMI are risk factors for several types of cancer and may be related to circulating concentrations of insulin-like growth factor-I (IGF-I), a peptide associated with increased cancer risk. Aim: To assess the associations between height, BMI and serum concentrations of IGF-I and IGF binding protein (IGFBP)-1, -2 and -3. Subjects and methods: This cross-sectional analysis included 1142 men and 3589 women aged 32-77 years from the multi-centre study, the European Prospective Investigation of Cancer and Nutrition (EPIC). Results: In men, there was a positive association between height and IGF-I; each 10 cm increment in height was associated with an increase in IGF-I concentrations of 4.3% (95% confidence interval (CI): 1.3-7.5%, p for trend = 0.005), but this association was not statistically significant for women (0.9%, 95% CI: -0.7 to 2.6%, p for trend = 0.264). In both men and women, the association between IGF-I and BMI was non-linear and those with a BMI of 26-27 kg/m(2) had the highest IGF-I concentration. BMI was strongly inversely related to concentrations of IGFBP-1 and IGFBP-2 in men and in women (p for trend for all < 0.001). Conclusion: Height and BMI are associated with IGF-I and its binding proteins, which may be mechanisms through which body size contributes to increased risk of several cancers.

引用

页码：194 / 202

页数：9

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