The polyacetylene falcarindiol with COX-1 activity isolated from Aegopodium podagraria L.

被引：25

作者：

Prior, Rikke M.

Lundgaard, Nanna H.

Light, Mamie E.

Stafford, Gary I.

van Staden, Johannes

Jaeger, Anna K.

机构：

[1] Danish Univ Pharmaceut Sci, Dept Med Chem, DK-2100 Copenhagen O, Denmark

[2] Univ KwaZulu Natal Pietermaritzburg, Sch Biol & Conservat Sci, Res Ctr Plant Growth & Dev, ZA-3209 Scottsville, South Africa

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2007年 / 113卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

aegopodium podagraria; COX-1; falcarindiol; quantitative HPLC analysis;

D O I：

10.1016/j.jep.2007.05.005

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Extracts of Aegopodium podagraria L. were screened in vitro for cyclooxygenase-1 (COX-1) inhibitory activity. The isolation of the active compound falcarindiol was achieved by bioassay-guided fractionation. The identification of the active compound was confirmed by H-1 NMR and C-13 NMR. The IC50-value of falcarindiol was 0.3 mu M in the COX- 1 assay. A quantitative determination of the seasonal variation in the content of falcarindiol in different plant parts was carried out by HPLC analysis. The flowers from Aegopodium podagraria collected in June 2006 had the highest concentration of falcarindiol (88 mg/g plant material). (c) 2007 Elsevier Ireland Ltd. All rights reserved.

引用

页码：176 / 178

页数：3

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