Chiari I malformation and idiopathic growth hormone deficiency in siblings: report of three cases

被引：9
|
作者：
Murphy, R. Lee
Tubbs, R. Shane
Grabb, Paul A.
Oakes, W. Jerry
机构：
[1] Childrens Hosp, Birmingham, AL 35233 USA
[2] Univ Alabama, Dept Cell Biol, Birmingham, AL 35294 USA
[3] Univ Alabama, Sch Med, Birmingham, AL USA
来源：
CHILDS NERVOUS SYSTEM | 2007年 / 23卷 / 10期
关键词：
hindbrain; tonsillar ectopia; posterior fossa;
D O I：
10.1007/s00381-007-0374-x
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Introduction The authors report a case of three brothers. Case descriptions Two of these siblings presented with congenital growth hormone deficiency (GHD) and Chiari I malformation (CIM). The third younger brother has been found not to have GHD or the CIM. Discussion Sparse cases of these two clinical occurrences have been reported. Further, the posterior cranial fossa (PF) has been determined to be altered in patients with CIM and GHD. Conclusion Our current case reports strengthen the association between these two pathological entities and, to our knowledge, is the first description of both defects in siblings.
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收藏
页码：1221 / 1223
页数：3
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